Evidence map›Paper›PMID 39872416›Full record

ArticleFrontiers in physiology2024

On the substrate turnover rate of NBCe1 and AE1 SLC4 transporters: structure-function considerations.

Alexander Pushkin, Liyo Kao, Hristina R Zhekova, Rustam Azimov, Natalia Abuladze, Xuesi M Shao, D Peter Tieleman, Ira Kurtz

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in physiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Alexander PushkinDepartment of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, United States.
Liyo KaoDepartment of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, United States.
Hristina R ZhekovaCentre for Molecular Simulation, Department of Biological Sciences, University of Calgary, Calgary, AB, Canada.
Rustam AzimovDepartment of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, United States.
Natalia AbuladzeDepartment of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, United States.
Xuesi M ShaoDepartment of Neurobiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, United States.
D Peter TielemanCentre for Molecular Simulation, Department of Biological Sciences, University of Calgary, Calgary, AB, Canada.
Ira KurtzDepartment of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, United States.

Funding

The Biology of NBCe1 in Health and DiseaseR01DK077162 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI IRA KURTZ · 2007 to 2026
$6.7M
NIDDK NIH HHS R01 DK077162
6 · The paper itself

Abstract

A transport protein's turnover rate (TOR) is the maximum rate of substrate translocation under saturating conditions. This parameter represents the number of transporting events per transporter molecule (assuming a single transport site) per second (s). From this standpoint, a transporter's TOR is similar to an enzyme's catalytic constant. Knowledge of a transporter's TOR allows comparison of the transport capacity of various transporters at the molecular level as well as the total transport per cell and whole organ levels. Despite this, there is currently a very limited number of transporters, for which TOR has been determined experimentally. In the SLC4 transporter family of CO

Indexed as

AE1bicarbonatecarbonateion turnover rateNBCe1-Arenal tubular acidosistransport

Identifiers

PMID39872416
PMCPMC11769940

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.