Evidence map›Paper›PMID 39872211›Full record

ArticleBioactive materials2025

Bioaugmented design and functional evaluation of low damage implantable array electrodes.

Ling Wang, Chenrui Zhang, Zhiyan Hao, Siqi Yao, Luge Bai, Joaquim Miguel Oliveira, Pan Wang, Kun Zhang, Chen Zhang, Jiankang He and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioactive materials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Ling WangState Key Laboratory for Manufacturing System Engineering, School of Mechanical Engineering, Xi'an Jiaotong University, China.
Chenrui ZhangState Key Laboratory for Manufacturing System Engineering, School of Mechanical Engineering, Xi'an Jiaotong University, China.
Zhiyan HaoState Key Laboratory for Manufacturing System Engineering, School of Mechanical Engineering, Xi'an Jiaotong University, China.
Siqi YaoState Key Laboratory for Manufacturing System Engineering, School of Mechanical Engineering, Xi'an Jiaotong University, China.
Luge BaiState Key Laboratory for Manufacturing System Engineering, School of Mechanical Engineering, Xi'an Jiaotong University, China.
Joaquim Miguel Oliveira3B's Research Group, I3Bs - Research Institute on Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, AvePark, Zona Industrial da Gandra, Barco, 4805-017, Guimarães, Portugal.
Pan WangDepartment of Anatomy, Histology and Embryology and K.K. Leung Brain Research Centre, The Fourth Military 9 Medical University, 710032, Xi'an, China.
Kun ZhangDepartment of Pharmacology, School of Pharmacy, Fourth Military Medical University, Xi'an, 710032, China.
Chen ZhangTianjin Medical Devices Quality Supervision and Testing Center, Tianjin, 300384, China.
Jiankang HeState Key Laboratory for Manufacturing System Engineering, School of Mechanical Engineering, Xi'an Jiaotong University, China.
Rui L Reis3B's Research Group, I3Bs - Research Institute on Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, AvePark, Zona Industrial da Gandra, Barco, 4805-017, Guimarães, Portugal.
Dichen LiState Key Laboratory for Manufacturing System Engineering, School of Mechanical Engineering, Xi'an Jiaotong University, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Implantable neural electrodes are key components of brain-computer interfaces (BCI), but the mismatch in mechanical and biological properties between electrode materials and brain tissue can lead to foreign body reactions and glial scarring, and subsequently compromise the long-term stability of electrical signal transmission. In this study, we proposed a new concept for the design and bioaugmentation of implantable electrodes (bio-array electrodes) featuring a heterogeneous gradient structure. Different composite polyaniline-gelatin-alginate based conductive hydrogel formulations were developed for electrode surface coating. In addition, the design, materials, and performance of the developed electrode was optimized through a combination of numerical simulations and physio-chemical characterizations. The long-term biological performance of the bio-array electrodes were investigated

Indexed as

Bioaugmented designBiocompatibilityImplantable neural electrodesScar tissue suppressionSignal-to-noise ratio

Identifiers

PMID39872211
PMCPMC11762938

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.