Evidence map›Paper›PMID 39872052›Full record

ArticleFrontiers in pharmacology2024

Effect of ultrasound combined with microbubbles therapy on tumor hypoxic microenvironment.

Yuyi Feng, Danxia Qiu, Yangcheng He, Hai Jin, Liping Chen, Fen Xi, Zhiwen Hu, Yanlin Xie, Yucai Li, Minhua Lin and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in pharmacology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Yuyi Feng *Department of Ultrasound, Guangzhou First People's Hospital, South China University of Technology, Guangzhou, China.
Danxia Qiu *Department of Ultrasound, Guangzhou First People's Hospital, South China University of Technology, Guangzhou, China.
Yangcheng He *Department of Ultrasound, Guangzhou First People's Hospital, South China University of Technology, Guangzhou, China.
Hai JinDepartment of Ultrasound, Guangzhou First People's Hospital, South China University of Technology, Guangzhou, China.
Liping ChenDepartment of Ultrasound, Guangzhou First People's Hospital, South China University of Technology, Guangzhou, China.
Fen XiDepartment of Ultrasound, Guangzhou First People's Hospital, South China University of Technology, Guangzhou, China.
Zhiwen HuDepartment of Ultrasound, Guangzhou First People's Hospital, South China University of Technology, Guangzhou, China.
Yanlin XieDepartment of Ultrasound, Guangzhou First People's Hospital, South China University of Technology, Guangzhou, China.
Yucai LiDepartment of Ultrasound, Guangzhou First People's Hospital, South China University of Technology, Guangzhou, China.
Minhua LinDepartment of Ultrasound, Guangzhou First People's Hospital, South China University of Technology, Guangzhou, China.
Pengxiao SunDepartment of Ultrasound, Guangzhou First People's Hospital, South China University of Technology, Guangzhou, China.
Yan HeDepartment of Ultrasound, Guangzhou First People's Hospital, South China University of Technology, Guangzhou, China.
Jianhua LiuDepartment of Ultrasound, Guangzhou First People's Hospital, South China University of Technology, Guangzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Tumor tissues exhibit significantly lower oxygen partial pressure compared to normal tissues, leading to hypoxia in the tumor microenvironment and result in resistance to tumor treatments. Strategies to mitigate hypoxia include enhancing blood perfusion and oxygen supply, for example,by decomposing hydrogen peroxide within the tumor. Improving hypoxia in the tumor microenvironment could potentially improve the efficacy of cancer treatments. Previous studies have demonstrated that ultrasound of appropriate intensity when combined with microbubbles, can improve tumor blood perfusion. However, its effects on tumor hypoxia remain unclear. This study aimed to assess the effects of low-frequency non-focused ultrasound combined with microbubbles at different intensities on tumor microenvironment hypoxia and to identify the optimal ultrasound parameters for alleviating tumor hypoxia. Method: Rabbits with VX2 tumors received ultrasound and microbubble treatments at different acoustic pressures and pulse repetition frequencies. The changes in tumor tissue blood perfusion before and after treatment were observed by contrast enhanced ultrasound (CEUS). The changes in tumor tissue hypoxia before and after treatment were observed by measuring oxygen partial pressure directly with in tumor tissue and immunohistochemical staining for hypoxia-inducible factor-1α (HIF-1α). Results: Results indicated that low frequency, non-focused ultrasound at 0.5 MPa/20 Hz and 0.5 MPa/40 Hz, when combined with microbubbles, could increase tumor tissue blood perfusion and improve the hypoxia in tumor tissues. Discussion: This study provides a new method for improving hypoxia in the tumor microenvironment (TME) which could potentially improve the cancer treatments resistance.

Indexed as

blood perfusioncontrast enhance ultrasoundhypoxiamicrobubblesoxygen partial pressuretumor hypoxic microenvironmentultrasound

Identifiers

PMID39872052
PMCPMC11769831

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.