Evidence map›Paper›PMID 39871868›Full record

ArticleIn vitro models2022

Evaluation of calcium phosphate-coated polycaprolactone/graphene oxide scaffold with macro- and microporous structure for bone tissue engineering.

Se Eun Kim, Na Eun Kim, Sunjae Park, Joo Hee Choi, Youngeun Song, Nomin-Erdene Tumursukh, Jina Youn, Jeong Eun Song, Gilson Khang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in In vitro models, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Se Eun KimDepartment of Bionanotechnology and Bio-Convergence Engineering, Jeonbuk National University, 567 Baekje-daero, Deokjin-gu, Jeonju-si, Jeonbuk, 54896 Korea.
Na Eun KimDepartment of Bionanotechnology and Bio-Convergence Engineering, Jeonbuk National University, 567 Baekje-daero, Deokjin-gu, Jeonju-si, Jeonbuk, 54896 Korea.
Sunjae ParkDepartment of Bionanotechnology and Bio-Convergence Engineering, Jeonbuk National University, 567 Baekje-daero, Deokjin-gu, Jeonju-si, Jeonbuk, 54896 Korea.
Joo Hee ChoiDepartment of Bionanotechnology and Bio-Convergence Engineering, Jeonbuk National University, 567 Baekje-daero, Deokjin-gu, Jeonju-si, Jeonbuk, 54896 Korea.
Youngeun SongDepartment of Bionanotechnology and Bio-Convergence Engineering, Jeonbuk National University, 567 Baekje-daero, Deokjin-gu, Jeonju-si, Jeonbuk, 54896 Korea.
Nomin-Erdene TumursukhDepartment of Bionanotechnology and Bio-Convergence Engineering, Jeonbuk National University, 567 Baekje-daero, Deokjin-gu, Jeonju-si, Jeonbuk, 54896 Korea.
Jina YounDepartment of Bionanotechnology and Bio-Convergence Engineering, Jeonbuk National University, 567 Baekje-daero, Deokjin-gu, Jeonju-si, Jeonbuk, 54896 Korea.
Jeong Eun SongDepartment of Bionanotechnology and Bio-Convergence Engineering, Jeonbuk National University, 567 Baekje-daero, Deokjin-gu, Jeonju-si, Jeonbuk, 54896 Korea.
Gilson KhangDepartment of Bionanotechnology and Bio-Convergence Engineering, Jeonbuk National University, 567 Baekje-daero, Deokjin-gu, Jeonju-si, Jeonbuk, 54896 Korea.ORCID 0000-0002-6452-5653

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: This study aimed to fabricate porous PCL/GO scaffolds by adding graphene oxide (GO) which is a hydrophilic material to improve cell affinity of PCL. Calcium phosphate (CaP) coating was performed to enhance the bioactivity of the composite scaffold. The phase separation methods and the salt leaching process were used to impart high porosity and pores of various sizes in the scaffolds. Methods: The scaffolds were characterized by scanning electron microscopy (SEM), energy-dispersive X-ray spectrometry (EDS), water contact angle test, swelling test, and mechanical tests. For in vitro evaluation, cell morphology and viability test, alkaline phosphatase (ALP) activity, and double-stranded DNA (dsDNA) quantification were performed using mouse bone marrow stem cells (mBMSCs). Results: All scaffolds had interconnected pore networks for transporting nutrients, oxygen, and waste products. GO addition and CaP coating improved hydrophilicity, swelling behavior, mechanical properties, and cell proliferation properties of the scaffolds by creating a biomimetic 3D microenvironment. The PCL/GO/CaP scaffold laden with mBMSCs had no clear cytotoxicity and further promoted osteogenic differentiation compared to the groups without GO or CaP. Conclusions: Our results suggest that the porous PCL/GO/CaP scaffold showed enhanced hydrophilicity and swelling behavior and exerted beneficial effects on cell proliferation and differentiation. This composite scaffold shows potential for clinical application in bone tissue engineering.

Indexed as

Bone tissue engineeringCalcium phosphateGraphene oxidePolycaprolactoneScaffoldsSimulated body fluid

Identifiers

PMID39871868
PMCPMC11756476

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.