Hormonal Regulation of Urokinase- and Tissue-Type Plasminogen Activator in Mouse Sertoli Cells.

Sara Carosi, Federica Innocenti, Lucia Monaco, Gaia Laurenzi, Rossana Saracino, Rita Canipari, Elena Vicini

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Article in Molecular reproduction and development, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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7 authors.

Sara CarosiDepartment of Anatomy, Histology, Forensic Medicine and Orthopedic, Section of Histology, Sapienza University of Rome, Rome, Italy.

Federica InnocentiDepartment of Anatomy, Histology, Forensic Medicine and Orthopedic, Section of Histology, Sapienza University of Rome, Rome, Italy.

Lucia MonacoDepartment of Physiology and Pharmacology, Sapienza University of Rome, Rome, Italy.

Gaia LaurenziDepartment of Anatomy, Histology, Forensic Medicine and Orthopedic, Section of Histology, Sapienza University of Rome, Rome, Italy.

Rossana SaracinoDepartment of Anatomy, Histology, Forensic Medicine and Orthopedic, Section of Histology, Sapienza University of Rome, Rome, Italy.

Rita CanipariDepartment of Anatomy, Histology, Forensic Medicine and Orthopedic, Section of Histology, Sapienza University of Rome, Rome, Italy.

Elena ViciniDepartment of Anatomy, Histology, Forensic Medicine and Orthopedic, Section of Histology, Sapienza University of Rome, Rome, Italy.ORCID 0000-0003-0399-0145

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6 · The paper itself

Abstract

A role for the plasminogen activator (PA) system has been postulated in mammalian gonads, considering the complex process of morphogenesis these organs undergo during their development. Our results show that mouse Sertoli cells under basal conditions produce both types of PA, tissue-type PA (tPA) and urokinase-type PA (uPA), and hormonal treatments increase the production of both enzymes. The increased enzyme secretion does not correlate with a parallel increase in their mRNAs. However, the proteolytic activity results from a balance between enzyme activity and inhibitors. Hormonal stimulation decreased the expression of the inhibitor PAI-1, suggesting that the increase in proteolytic activity might depend on the decreased production of PAI-1. The expression of the two enzymes and their inhibitor depends on the seminiferous epithelium stage. We observed higher uPA mRNA levels at stages VII-VIII and IX-XII, tPA peaks at stages VII-VIII, and PAI-1 mRNA levels decreased at stages VII-VIII and IX-XII. The testes from mice lacking the uPA gene (uPA

Indexed as

Sertoli CellsTissue Plasminogen ActivatorUrokinase-Type Plasminogen ActivatorAnimalsMaleMiceMice, Inbred C57BLMice, KnockoutPlasminogen Activator Inhibitor 1TestisPlasminogen Activator Inhibitor 1Tissue Plasminogen ActivatorUrokinase-Type Plasminogen Activatorplasminogen activatorSertoli cellsuPA−/− mice

Identifiers

PMID39871771

DOI10.1002/mrd.70012

PMCPMC11773371

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