ArticleAdvanced materials (Deerfield Beach, Fla.)2025
Oriented Cortical-Bone-Like Silk Protein Lamellae Effectively Repair Large Segmental Bone Defects in Pigs.
Article in Advanced materials (Deerfield Beach, Fla.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Regulating Cells Fate and Function to Facilitate Bone Regeneration via Designing Programmable Bio-Interactive Materials.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Biodegradable MgBioactive materials · 2026Article
- Freeze-Derived Microporous Biomaterials for Tissue Engineering Applications.Smart medicine · 2026Review
- Organoids: generation strategies, applications, and future challenges.Stem cell research & therapy · 2026Review
- Feasibility of Ti-6Al-4V Alloys with Nanoporous and Nanotubular Surfaces for the Treatment of Femoral Defects.International journal of molecular sciences · 2026Article
- Bone Organoids: A Novel Tool for Modeling and Managing Skeletal Disorders in Diabetes.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- NIR-responsive smart hydrogel incorporating LF-decorated nanosheets recalibrating the immune-vascular-osteogenic microenvironment for enhanced bone regeneration.Journal of nanobiotechnology · 2026Article
- Manganese-doped nano-hydroxyapatite enhances CF/PEEK osseointegration via immunomodulation-osteogenesis coupling.Regenerative biomaterials · 2026Article
- Whitlockite-loaded silk fibroin/polyvinyl alcohol hydrogel composited with porous tantalum scaffold enhances bone regeneration and immunomodulation via the TGF-β/NRROS signaling pathway.Materials today. Bio · 2025Article
- Hematoma-inspired injectable composite hydrogels incorporating hybrid metal ion microspheres for accelerated bone regeneration.Materials today. Bio · 2025Article
- Multi-scale biomimetic fusion construction of cerium ion hydrogel-scaffold for promoting osteoporotic bone defect repair.Journal of orthopaedic translation · 2025Article
- Hydrogels with programmed spatiotemporal mechanical cues for stem cell-assisted bone regeneration.Nature communications · 2025Article
- Oriented Cortical-Bone-Like Silk Protein Lamellae Effectively Repair Large Segmental Bone Defects in Pigs.Advanced materials (Deerfield Beach, Fla.) · 2025Article
- From niche to organoid: Engineering bone tissues through microenvironmental insights.Journal of tissue engineeringReview
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Assembling natural proteins into large, strong, bone-mimetic scaffolds for repairing bone defects in large-animal load-bearing sites remain elusive. Here this challenge is tackled by assembling pure silk fibroin (SF) into 3D scaffolds with cortical-bone-like lamellae, superior strength, and biodegradability through freeze-casting. The unique lamellae promote the attachment, migration, and proliferation of tissue-regenerative cells (e.g., mesenchymal stem cells [MSCs] and human umbilical vein endothelial cells) around them, and are capable of developing in vitro into cortical-bone organoids with a high number of MSC-derived osteoblasts. High-SF-content lamellar scaffolds, regardless of MSC inoculation, regenerated more bone than non-lamellar or low-SF-content lamellar scaffolds. They accelerated neovascularization by transforming macrophages from M1 to M2 phenotype, promoting bone regeneration to repair large segmental bone defects (LSBD) in minipigs within three months, even without growth factor supplements. The bone regeneration can be further enhanced by controlling the orientation of the lamella to be parallel to the long axis of bone during implantation. This work demonstrates the power of oriented lamellar bone-like protein scaffolds in repairing LSBD in large animal models.
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Registered trials
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