Evidence map›Paper›PMID 39871665›Full record

ArticleJournal of oral rehabilitation2025

Oral Dysaesthetic and Perceptual Disorder, A Distinct Subset of Chronic Orofacial Pain Without Burning Symptoms: A Case-Control Study.

Gennaro Musella, Federica Canfora, Vito Carlo Alberto Caponio, Emmanouil Vardas, Maria Kouri, Nikolaos Nikitakis, Giuseppe Troiano, Massimo Aria, Luca D'Aniello, Lorenzo Lo Muzio and 2 more

Abstract read
In one paragraph

Article in Journal of oral rehabilitation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Burning mouth syndrome: updates on pathogenesis and diagnostic algorithms.Journal of oral & facial pain and headache · 2025
    Review
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Gennaro MusellaDepartment of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy.ORCID https://orcid.org/0009-0005-3576-4670
Federica CanforaDepartment of Neuroscience, Reproductive Sciences, and Dentistry, University of Naples Federico II, Naples, Italy.ORCID https://orcid.org/0000-0002-4610-6690
Vito Carlo Alberto CaponioDepartment of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy.ORCID https://orcid.org/0000-0001-5080-5921
Emmanouil VardasDepartment of Oral Medicine and Pathology and Hospital Dentistry, National and Kapodistrian University of Athens, Athens, Greece.
Maria KouriDepartment of Oral Medicine and Pathology and Hospital Dentistry, National and Kapodistrian University of Athens, Athens, Greece.
Nikolaos NikitakisDepartment of Oral Medicine and Pathology and Hospital Dentistry, National and Kapodistrian University of Athens, Athens, Greece.
Giuseppe TroianoDepartment of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy.
Massimo AriaDepartment of Economics and Statistics, University of Naples Federico II, Naples, Italy.
Luca D'AnielloDepartment of Social Sciences, University of Naples Federico II, Naples, Italy.
Lorenzo Lo MuzioDepartment of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy.
Michele Davide MignognaDepartment of Neuroscience, Reproductive Sciences, and Dentistry, University of Naples Federico II, Naples, Italy.
Daniela AdamoDepartment of Neuroscience, Reproductive Sciences, and Dentistry, University of Naples Federico II, Naples, Italy.ORCID https://orcid.org/0000-0002-3784-4229

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAccording to the ICOP 2020, Burning Mouth Syndrome (BMS) is a chronic orofacial pain disorder characterised by an intraoral burning sensation, which represents the main diagnostic criterion. However, some patients experience other symptoms such as xerostomia, taste alterations, and globus, without the burning sensation (non-BMS).

objectiveThis study aims to explore non-BMS as a distinct subclinical entity by comparing the classical BMS with this new group of patients in a case-control study, addressing gaps in current diagnostic criteria.

methodsEighty-three non-BMS patients were compared with an equal number of BMS patients matched for age and sex. Data on sociodemographic and risk factors, systemic comorbidities and drug intake, symptom patterns, psychological profiles were collected and statistically analysed.

resultsNo significant differences between BMS and non-BMS groups were found in sociodemographic characteristics, comorbidities, drug consumption and extraoral symptoms. Both groups reported similar symptoms patterns, with discomfort intensifying in the evening. Although oral symptoms prevalence varied, with the burning sensation exclusive to BMS patients, none of these differences reached statistical significance. Psychological assessments revealed mild depression (17 [14-19] vs. 17 [14-20], p  0.981), mild to moderate anxiety (18 [15-21] vs. 17 [15-20.5], p = 0.767), and sleep disturbance (5 [4-7] vs. 8 [5-10], p < 0.001) in both groups.

conclusionNon-BMS patients exhibit similarities to BMS patients yet remain unclassified under current diagnostic criteria. Therefore, we have suggested the term "Oral Dysaesthetic and Perceptual Disorder (ODPD)" to define these patients (non-BMS). This study emphasises the need to expand diagnostic criteria to better identify and manage ODPD patients.

Indexed as

Burning Mouth SyndromeChronic PainFacial PainPerceptual DisordersAdultAgedCase-Control StudiesFemaleHumansMaleMiddle Agedburning mouth syndromedysgeusiamisperceptionsomatic symptom disorderxerostomia

Identifiers

PMID39871665
PMCPMC12037929

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.