ArticleAdvanced materials (Deerfield Beach, Fla.)2025
Xolography for Biomedical Applications: Dual-Color Light-Sheet Printing of Hydrogels With Local Control Over Shape and Stiffness.
Article in Advanced materials (Deerfield Beach, Fla.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed.
- In Situ Characterisation of Hydrogels via Dynamic Interface Printing.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Bioprinting Organs-Science or Fiction?-A Review From Students to Students.Advanced healthcare materials · 2026Review
- 3D biofabricated in vitro models as new approach methodologies for animal alternatives.npj biomedical innovations · 2026Review
- Gravity-Tolerant In-Flight 3D Bioprinting Enabled by Stereolithography for Space Tissue Engineering.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Unconventional bioprinting modalities for advanced tissue biofabrication.Biomaterials · 2026Review
- Geometrical Designs in Volumetric Bioprinting to Study Cellular Behaviors in Engineered Constructs.Advanced healthcare materials · 2026Article
- Biocompatible Ink Optimization Enables Functional Volumetric Bioprinting With Xolography.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Vat Photopolymerization of Smart Polymers for Biomedical Applications.ACS applied polymer materials · 2025Review
- Xolography for Rapid Volumetric Production of Objects from the Nanoscopic to Macroscopic Length Scales.Advanced materials (Deerfield Beach, Fla.) · 2025Article
- Bridging the Gap: Unlocking the Potential of Biofabrication for Applications in In Vitro Testing.Langmuir : the ACS journal of surfaces and colloids · 2025Review
- Biofabrication in suspension media-a decade of advances.Biofabrication · 2025Review
- Xolography for Biomedical Applications: Dual-Color Light-Sheet Printing of Hydrogels With Local Control Over Shape and Stiffness.Advanced materials (Deerfield Beach, Fla.) · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
Current challenges in tissue engineering include creation of extracellular environments that support and interact with cells using biochemical, mechanical, and structural cues. Spatial control over these cues is currently limited due to a lack of suitable fabrication techniques. This study introduces Xolography, an emerging dual-color light-sheet volumetric printing technology, to achieve control over structural and mechanical features for hydrogel-based photoresins at micro- to macroscale while printing within minutes. A water-soluble photoswitch photoinitiator system and a library of naturally-derived, synthetic, and thermoresponsive hydrogels for Xolography are proposed. Centimeter-scale, 3D constructs with positive features of 20 µm and negative features of ≈100 µm are fabricated with control over mechanical properties (compressive moduli 0.2 kPa-6.5 MPa). Notably, switching from binary to grayscaled light projection enables spatial control over stiffness (0.2-16 kPa). As a proof of concept, grayscaled Xolography is leveraged with thermoresponsive hydrogels to introduce reversible anisotropic shape changes beyond isometric shrinkage. Xolography of viable cell aggregates is finally demonstrated, laying the foundation for cell-laden printing of dynamic, cell-instructive environments with tunable structural and mechanical cues in a fast one-step process. Overall, these innovations unlock unique possibilities of Xolography across multiple biomedical applications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.