Evidence map›Paper›PMID 39871573›Full record

ReviewCurrent medicinal chemistry2026

Achievements and Approaches in the Search for Small-Molecule Dengue NS2B/NS3 Inhibitors.

Khac-Minh Thai, Cuong Quoc Duong, Tan Thanh Mai, Minh-Tri Le, Van-Thanh Tran, Phuoc-Vinh Nguyen, Lam-Truong Tuong

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current medicinal chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Khac-Minh ThaiUniversity of Health Sciences, Vietnam National University Ho Chi Minh City, Ho Chi Minh City, Vietnam.ORCID 0000-0002-5279-9614
Cuong Quoc DuongFaculty of Pharmacy, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Vietnam.ORCID 0000-0002-6716-9447
Tan Thanh MaiFaculty of Pharmacy, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Vietnam.ORCID 0000-0001-7313-9853
Minh-Tri LeUniversity of Health Sciences, Vietnam National University Ho Chi Minh City, Ho Chi Minh City, Vietnam.ORCID 0000-0002-5105-9710
Van-Thanh TranFaculty of Pharmacy, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Vietnam.ORCID 0000-0002-4976-0436
Phuoc-Vinh NguyenUniversity of Health Sciences, Vietnam National University Ho Chi Minh City, Ho Chi Minh City, Vietnam.ORCID 0000-0002-7421-1623
Lam-Truong TuongFaculty of Pharmacy, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Vietnam.ORCID 0009-0009-7285-4252

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

With the escalation of viral infections in recent decades, including the COVID- 19 pandemic, viral infectious diseases have increasingly become a global concern, attracting significant attention. Among many viral epidemics, the dengue virus, an RNA virus from the Flaviviridae family, has been reported by the WHO as one of the most prevalent mosquito-borne diseases, infecting roughly 400 million people yearly and spreading across all continents worldwide. In the last two decades, researchers from academia and industry have diligently studied many aspects of the virus, including its structure, life cycle, potential therapeutic agents, and vaccines. Dengvaxia

Indexed as

Antiviral AgentsDengue VirusProtease InhibitorsSmall Molecule LibrariesViral Nonstructural ProteinsAnimalsDEAD-box RNA HelicasesDengueDrug DiscoveryHumansNucleoside-TriphosphataseRNA HelicasesSerine EndopeptidasesViral ProteasesAntiviral AgentsDEAD-box RNA Helicasesnonstructural protein 2B, Dengue virusNS2B protein, flavivirusNS3 protease, dengue virusNucleoside-TriphosphataseProtease InhibitorsRNA HelicasesSerine EndopeptidasesSmall Molecule LibrariesViral Nonstructural ProteinsViral Proteasesdengue fever drug discoveryDengue virusin vitronatural substanceNS2B/NS3 proteaseprotease assaystructural-activity relationship

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.