Evidence map›Paper›PMID 39871554›Full record

Trial reportInfectious disorders drug targets2025

A Clinical Multicenter Trial of Recombinant Human Interferon Gamma in Tuberculosis (GAM2022): Experience with the Use of Human Recombinant Interferon Gamma in TB Practice.

Veronika E Izosimova, Natal'ja A Barmina, Marija P Zharikova, Oleg Y Alekseyev, Oxana A Ryzhkova, Marat H Sayfulin, Natal'ja A Popova, Mihail A Andreyev, Svetlana G Gagarina, Raisa M Rysdauletova and 3 more

Registry-linked trialAbstract readMulticenter StudyClinical Trial
PubMed Publisher
In one paragraph

Trial report in Infectious disorders drug targets, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06118619 (A Multicenter Clinical Trial of Recombinant Human Interferon Gamma), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06118619 unknown statusnot on this map

A Multicenter Clinical Trial of Recombinant Human Interferon Gamma (Ingaron) in Pulmonary Tuberculosis

TypeobservationalSponsorSPP Pharmaclon Ltd.Ran2022 to 2024Enrolled350ConditionsRespiratory TuberculosisArmsInterferon-Gamma
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Veronika E IzosimovaTuberculosis Clinic of the Republic of Bashkortostan, 4 Sagita Agisha St., Ufa, 450080, Russia.ORCID 0009-0009-7787-2257
Natal'ja A BarminaLeningrad Oblast Tuberculosis Clinic, 20 Lenina St., Slantsy, 188560, Russia.ORCID 0000-0001-6061-9591
Marija P ZharikovaRyazan Oblast Tuberculosis Clinic, 5 Golenchinskoye Hwy, Ryazan, 390046, Russia.ORCID 0009-0006-4419-5788
Oleg Y AlekseyevN. S. Pokhvisneva Voronezh Oblast Clinical Tuberculosis Dispensary, 1 Teplichnaya St., Voronezh, 394070, Russia.ORCID 0009-0006-9743-3567
Oxana A RyzhkovaAstrakhan Oblast Tuberculosis Clinic, 7 liter U Nachalovskoye Hwy, Astrakhan, 414004, Russia.ORCID 0009-0006-9910-0678
Marat H SayfulinAstrakhan Oblast Tuberculosis Clinic, 7 liter U Nachalovskoye Hwy, Astrakhan, 414004, Russia.ORCID 0009-0007-6869-8723
Natal'ja A PopovaAstrakhan Oblast Tuberculosis Clinic, 7 liter U Nachalovskoye Hwy, Astrakhan, 414004, Russia.ORCID 0009-0008-1117-1151
Mihail A AndreyevTuberculosis Clinic of the Chuvash Republic, 4V Pirogova St., Cheboksary, 428015, Russia.ORCID 0009-0002-2927-2547
Svetlana G GagarinaVolgograd Oblast Tuberculosis Clinic, 54 im. Lenina Ave, Volgograd, 400005, Russia.ORCID 0000-0002-2285-7107
Raisa M RysdauletovaLeningrad Oblast Tuberculosis Hospital in Tikhvin, 2 Shvedskiy Dr., Tikhvin, 187550, Russia.ORCID 0009-0001-5379-8947
Natal'ja G KamaevaSverdlovsk Oblast Clinical Medical Center of Phthisiopulmonology and Infectious Diseases, 9a Chapayeva St., Yekaterinburg, 620142, Russia.ORCID 0000-0003-2296-1518
Anastasiya G SamoylovaNational Medical Research Center of Phthisiopulmonology and Infectious Diseases, Russian Ministry of Health, 4 Dostoyevskogo St., bldg 2, Moscow, 127473, Russia.ORCID 0000-0001-6596-9777
Marija I RomanovaNational Medical Research Center of Phthisiopulmonology and Infectious Diseases, Russian Ministry of Health, 4 Dostoyevskogo St., bldg 2, Moscow, 127473, Russia.ORCID 0000-0002-4132-0049

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIn this article, we present the results of a multicenter clinical trial of IFN-γ in patients with drug-susceptible and drug-resistant pulmonary Tuberculosis (TB) in routine clinical practice.

objectiveThis study aimed to confirm the efficacy and safety of IFN-γ administered to patients with TB.

methodsAll patients were diagnosed with TB after being tested by bacterioscopic and molecular genetic methods and had no contraindications to standard chemotherapy.

resultsRecombinant human IFN-γ proved high efficacy in multi-center clinical trial in routine TB practice.

conclusionThe results show that IFN-γ is efficient and safe in the treatment of pulmonary tuberculosis. Clinical Trial Registration #: NCT06118619.

Indexed as

Antitubercular AgentsInterferon-gammaTuberculosis, Multidrug-ResistantTuberculosis, PulmonaryAdultAgedFemaleHumansMaleMiddle AgedMycobacterium tuberculosisRecombinant ProteinsTreatment OutcomeYoung AdultAntitubercular AgentsInterferon-gammaRecombinant Proteinsadult patientschemotherapy.IFN-γinterferon-gammamulticenter clinical trialTuberculosis

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.