Evidence map›Paper›PMID 39871343›Full record

ArticleActa neuropathologica communications2025

Management of asynchronous multifocal adult glioblastoma with loss of BRAF

Hannah Haile, Pavan S Upadhyayula, Esma Karlovich, Michael B Sisti, Brian J A Gill, Laura E Donovan

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta neuropathologica communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Hannah HaileDepartment of Neurological Surgery, Columbia University Irving Medical Center, New York, NY, 10032, USA.
Pavan S UpadhyayulaDepartment of Neurological Surgery, Columbia University Irving Medical Center, New York, NY, 10032, USA.
Esma KarlovichDepartment of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, 10032, USA.
Michael B SistiDepartment of Neurological Surgery, Columbia University Irving Medical Center, New York, NY, 10032, USA.
Brian J A GillDepartment of Neurological Surgery, Columbia University Irving Medical Center, New York, NY, 10032, USA.
Laura E DonovanDepartment of Neuro-Oncology, Columbia University Irving Medical Center, 710 W. 168th Street, New York, NY, 10032, USA. led2137@cumc.columbia.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Glioblastoma (GBM) classification involves a combination of histological and molecular signatures including IDH1/2 mutation, TERT promoter mutation, and EGFR amplification. Non-canonical mutations such as BRAF

Indexed as

Brain NeoplasmsGlioblastomaProto-Oncogene Proteins B-rafAgedHumansMaleMutationNeoplasm Recurrence, LocalTemozolomideBRAF protein, humanProto-Oncogene Proteins B-rafTemozolomideBRAF inhibitorsBRAFV600EClonal evolutionDabrafenibGlioblastomaGliomaResistance mechanismsTargeted therapyTrametinibTumor heterogeneity

Identifiers

PMID39871343
PMCPMC11773960

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.