ArticleBMC geriatrics2025
The obesity paradox in osteoporosis risk among older adults is mostly driven by women: a population-based prospective study.
Article in BMC geriatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Tracking Bone Loss in GLP-1RA Therapy: The Potential of the Deoxypyridinoline Urine Test.Diagnostics (Basel, Switzerland) · 2026Article
- Assessment of the effects of whole-body muscle and fat mass on bone mineral content based on 628 DXA datasets.Frontiers in endocrinology · 2026Article
- Multimodal AI Model for Sarcopenia Detection: Integrating Chest CT and Clinical Parameters in Older Adults.Clinical interventions in aging · 2026Article
- Underweight Status is Associated with Prevalent Anemia in Postmenopausal Women with Osteoporotic Vertebral Compression Fractures: A Cross-Sectional Study.Clinical interventions in aging · 2026Article
- L-shaped association of the non-high-density lipoprotein to high-density lipoprotein ratio with low bone mass disorders.Scientific reports · 2025Article
- Construction of a clinical prediction model for osteoporosis in asymptomatic elderly population based on machine learning algorithm.Frontiers in medicine · 2025Article
- Development of a machine learning-based predictive model for osteoporosis risk and its application in clinical decision support.Frontiers in medicine · 2025Article
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Authors and funding
11 authors.
Funding
Abstract
objectivesThe obesity paradox is common among older adults at risk for various diseases. Although this paradox has also been observed in the association between obesity and osteoporosis, the available evidence remains controversial. This study aimed to investigate the association between obesity and OP risk in an older population.
methodsA cross-sectional and prospective study was conducted using data from 177,734 participants in the UK Biobank. The association of body mass index (BMI), waist circumference (WC), and fat percentage with BMD was examined using Spearman correlation analysis with baseline BMD data. Cox proportional hazards regression analysis was used to investigate the association between obesity and OP risk. Restricted cubic spline (RCS) were used to assess the nonlinear associations of BMI, WC, and fat percentage with OP.
resultsBaseline cross-sectional analyses revealed a significant positive association between BMI, WC, and fat percentage with BMD in women, whereas this association was very weak in men. A total of 8,998 OP patients were identified during a median follow-up period of 13.7 years. Cox analyses showed that obesity as defined by BMI, WC, and fat percentage was associated with a 33%, 23%, and 31% reduction in the risk of OP in older women but not in men, respectively. Conjoint analysis showed that lower BMI was associated with increased risk of OP in older adults, whereas the lowest risk was observed in women with higher BMI and higher body fat. RCS revealed an inverse J-shaped nonlinear association between obesity metrics and OP risk in women.
conclusionLower BMI is an independent risk factor for OP in older adults, and the obesity paradox for OP risk exists only in women.
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