Evidence map›Paper›PMID 39871152›Full record

Trial reportBMC neurology2025

The effect of transcranial direct current stimulation and inhibitory control training on depression and anxiety among post-stroke individuals.

Csaba Kazinczi, Noemi Szepfalusi, Viola Luca Nemeth, Adrienn Holczer, Katalin Jakab, Laszlo Vecsei, Peter Klivenyi, Anita Must, Mihaly Racsmany

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Csaba KazincziDepartment of Neurology, University of Szeged, 6, Semmelweis Street, Szeged, 6725, Hungary. kazinczi.csaba@med.u-szeged.hu.ORCID http://orcid.org/0000-0002-7748-757X
Noemi SzepfalusiDepartment of Neurology, University of Szeged, 6, Semmelweis Street, Szeged, 6725, Hungary.ORCID http://orcid.org/0000-0003-0047-8496
Viola Luca NemethDepartment of Neurology, University of Szeged, 6, Semmelweis Street, Szeged, 6725, Hungary.ORCID http://orcid.org/0000-0003-4717-1774
Adrienn HolczerDepartment of Neurology, University of Szeged, 6, Semmelweis Street, Szeged, 6725, Hungary.ORCID http://orcid.org/0000-0003-0668-8080
Katalin JakabDepartment of Neurology, University of Szeged, 6, Semmelweis Street, Szeged, 6725, Hungary.ORCID http://orcid.org/0000-0002-5157-8625
Laszlo VecseiDepartment of Neurology, University of Szeged, 6, Semmelweis Street, Szeged, 6725, Hungary.ORCID http://orcid.org/0000-0001-8037-3672
Peter KlivenyiDepartment of Neurology, University of Szeged, 6, Semmelweis Street, Szeged, 6725, Hungary.ORCID http://orcid.org/0000-0002-5389-3266
Anita MustDepartment of Psychiatry, Whanganui District Health Board, 100 Heads Road, Whanganui, 4501, New Zealand.ORCID http://orcid.org/0000-0001-8029-2186
Mihaly RacsmanyUniversity of Szeged, Institute of Psychology, 2, Egyetem Street, Szeged, 6722, Hungary.ORCID http://orcid.org/0009-0006-6591-7233

Funding

EU-funded Hungarian Grant EFOP-3.6.3-16-2017-00002Hungarian Brain Research Program 2017-1.2.1-NKP-2017-00002 NAP VI/4
6 · The paper itself

Abstract

backgroundRecent research has highlighted the role of fronto-parietal brain networks and cognitive control in mood disorders. Transcranial direct current stimulation (tDCS) and computer-based cognitive training are used in post-stroke rehabilitation. This study examined the combined effects ofof computer-based inhibitory control training (ICCT) and anodal tDCS on post-stroke depression and anxiety.

methodsThirty-five participants were randomly assigned to one of three groups: active tDCS treatment (A), sham tDCS treatment with ICCT (T), or active tDCS with ICCT (AT), for a duration of ten days. Primary outcome measures included the Beck Depression Inventory (BDI), Hamilton Depression Rating Scale (HAM-D), and Spielberger's State-Trait Anxiety Inventory (STAI-S/T). Statistical analysis was performed using a Mixed-model Analysis of Variance, with supplementary Bayesian analysis.

resultsThe AT group showed a significant improvement in BDI scores (p < .001), whereas no significant effects were observed on the HAM-D, STAI-T, or STAI-S scales.

conclusionsThe combination of tDCS and ICCT reduced depressive symptoms as measured by the BDI; while no significant effects were found with either treatment alone. Further research is needed to explore the mechanisms behind the synergistic effects in the treatment of post-stroke mood disorders.

Indexed as

AnxietyCognitive Behavioral TherapyDepressionInhibition, PsychologicalStrokeStroke RehabilitationTranscranial Direct Current StimulationAdultAgedFemaleHumansMaleMiddle AgedPsychiatric Status Rating ScalesTreatment OutcomeAnxietyComputer-based cognitive trainingDepressionTDCS

Identifiers

PMID39871152
PMCPMC11770995

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.