ArticleGeroScience2025
Preserved brain youthfulness: longitudinal evidence of slower brain aging in superagers.
Article in GeroScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Your brain doesn't look a day past 70! Cross-sectional associations with brain-predicted age in the cognitively-intact oldest-old.GeroScience · 2026Article
- BrainAGE in superagers: cross-sectional and longitudinal analyses in older adults aged 80+ with youthful episodic memory.GeroScience · 2025Article
- Functional Connectome of Superagers Reveals Early Markers of Resilience and Vulnerability to Alzheimer's Disease.bioRxiv : the preprint server for biology · 2025Article
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Authors and funding
6 authors.
Funding
Abstract
backgroundSuperagers, older adults with exceptional cognitive abilities, show preserved brain structure compared to typical older adults. We investigated whether superagers have biologically younger brains based on their structural integrity.
methodsA cohort of 153 older adults (aged 61-93) was recruited, with 63 classified as superagers based on superior episodic memory and 90 as typical older adults, of whom 64 were followed up after two years. A deep learning model for brain age prediction, trained on 899 diverse-aged adults (aged 31-100), was adapted to the older adult cohort via transfer learning. Brain age gap (BAG), a metric based on brain structural patterns, defined as the difference between predicted and chronological age, and its annual rate of change were calculated to assess brain aging status and speed, respectively, and compared among subgroups.
resultsLower BAGs correlated with more favorable cognitive status in memory and general cognitive function. Superagers exhibited a lower BAG than typical older adults at both baseline and follow-up. Individuals who maintained or attained superager status at follow-up showed a slower annual rate of change in BAG compared to those who remained or became typical older adults.
conclusionsSuperaging brains manifested maintained neurobiological youthfulness in terms of a more youthful brain aging status and a reduced speed of brain aging. These findings suggest that cognitive resilience, and potentially broader functional resilience, exhibited by superagers during the aging process may be attributable to their younger brains.
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