ArticleSurgery today2025
Preoperative low prealbumin independently predicts non-gastric cancer death after gastrectomy in elderly and young patients: a retrospective cohort study.
Article in Surgery today, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed.
- Frailty assessed by comprehensive geriatric assessment and postoperative outcomes of older adults undergoing gastrectomy for gastric cancer.Surgery today · 2026Article
- Clinical significance of preoperative oral frailty and malnutrition in predicting the surgical outcomes of Gastrointestinal cancers.Surgery today · 2026Article
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8 authors.
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Abstract
purposeTo investigate the effect of preoperative prealbumin levels on long-term survival outcomes after gastrectomy in patients with gastric cancer (GC) dichotomized based on age.
methodsThis retrospective cohort study included consecutive patients who underwent radical gastrectomy for primary stage I-III GC between May 2006 and March 2017. Patients were allocated to groups based on age (≥ 70 or < 70 years) and subgroups based on prealbumin levels (high, ≥ 22 mg/dL; moderate, 15-22 mg/dL; or low, < 15 mg/dL), and multivariate Cox regression was used for survival analyses.
resultsOf 4732 patients, 3172 (67.0%) were aged < 70 years and 1560 (33.0%) were ≥ 70 years of age. The median follow-up period was 66 months. A low prealbumin level was an independent prognostic factor for poor overall survival in older patients only [hazard ratio, 2.057; 95% confidence interval, 1.528-2.770; P < 0.001]. A low prealbumin level was an independent prognostic factor for poor other-cause survival in the older (hazard ratio: 2.719, 95% confidence interval: 1.887-3.918, P < 0.001) and younger (HR: 4.611, 95% CI 2.424-8.772, P < 0.001) groups.
conclusionLow preoperative prealbumin levels were associated with poor overall survival in older patients with GC after gastrectomy and with earlier non-GC death in older and younger patients.
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