ArticleScientific reports2025
Preserved ratio impaired spirometry, airflow obstruction, and their trajectories in relationship to chronic kidney disease: a prospective cohort study.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Effects of Progressive Inspiratory Muscle Training on Lung Volume and Respiratory Strength in Patients With Pre-Dialysis Chronic Kidney Disease.Physiotherapy research international : the journal for researchers and clinicians in physical therapy · 2026Trial
- The Inflammation-Metabolism Axis in Preserved Ratio Impaired Spirometry: Pathogenic Mechanisms and Translational Implications.Journal of inflammation research · 2026Review
- The association between non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio and preserved ratio impaired spirometry: NHANES 2007-2012.Lipids in health and disease · 2025Article
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7 authors.
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Abstract
Spirometry findings, such as restrictive spirometry and airflow obstruction, are associated with renal outcomes. Effects of spirometry findings such as preserved ratio impaired spirometry (PRISm) and its trajectories on renal outcomes are unclear. This study aimed to investigate the impact of baseline and trajectories of spirometry findings on future chronic kidney disease (CKD) events. This UK Biobank cohort study included participants with CKD who underwent spirometry at baseline (2006-2010). Lung function trajectories were determined using baseline and follow-up spirometry (2014-2020). Cox proportional hazards multivariate regression analysis was used to analyze the association between lung function and the incident CKD. In the baseline analysis (n = 282,354), fully adjusted hazard ratios (HRs) for PRISm participants (vs. normal spirometry) were 1.20 (1.07-1.34) for CKD and 1.51 (1.04-2.19) for end-stage renal disease (ESRD). Over an average 13.8-year follow-up period, 789 participants developed CKD. Trajectory analysis revealed higher CKD incidence with persistent AO (HR = 1.47(1.03-2.12)) and PRISm (HR = 1.28(0.88-1.88)) compared to normal lung function. Transitioning from AO to PRISm was associated with lower CKD incidence (HR = 0.27(0.08-0.93)). Recovery of normal lung function from AO could avert 16% of CKD cases. Our study indicated that baseline PRISm and airflow obstruction are associated with higher risk of incident CKD. Moreover, those with persistent AO findings had a higher risk of CKD incidence. These findings underscore the complex link between spirometry findings and renal outcomes and highlight the importance of considering respiratory and renal health in clinical assessments.
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