Evidence map›Paper›PMID 39870672›Full record

Reviewnpj aging2025

NAD World 3.0: the importance of the NMN transporter and eNAMPT in mammalian aging and longevity control.

Shin-Ichiro Imai

Abstract readReview
In one paragraph

Review in npj aging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Domain-specific effects of NADFrontiers in nutrition · 2026
    Pooled it
  2. Pooled it
  3. Pooled it
  4. Article
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  11. Review
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  13. NADCells · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Shin-Ichiro ImaiDepartment of Developmental Biology, Department of Medicine (Joint), Washington University School of Medicine, St. Louis, Missouri, USA. imaishin@wustl.edu.ORCID http://orcid.org/0000-0003-3742-5777

Funding

ENAMPT-MEDIATED ADIPO-HYPOTHALAMIC COMMUNICATION FOR NAD+ PRODUCTION AND AGINGR01AG047902 · NIA · WASHINGTON UNIVERSITY · PI IMAI, SHIN-ICHIRO · 2014 to 2023
$3.2M
THE ROLE OF DORSOMEDIAL HYPOTHALAMIC NEURONS IN MAMMALIAN AGING AND LONGEVITYR01AG037457 · NIA · WASHINGTON UNIVERSITY · PI IMAI, SHIN-ICHIRO · 2011 to 2020
$3.1M
Japan Agency for Medical Research and Development (AMED) 21gm5010002s0003NIA NIH HHS R01 AG037457NIA NIH HHS R01 AG047902U.S. Department of Health & Human Services | NIH | National Institute on Aging (U.S. National Institute on Aging) AG037457U.S. Department of Health & Human Services | NIH | National Institute on Aging (U.S. National Institute on Aging) AG047902
6 · The paper itself

Abstract

Over the past five years, systemic NAD

Identifiers

PMID39870672
PMCPMC11772665

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.