Evidence map›Paper›PMID 39870079›Full record

ArticleClinical and translational science2025

In vitro comparative analysis of metabolic capabilities and inhibitory profiles of selected CYP2D6 alleles on tramadol metabolism.

Noor Ahmed Nahid, Siva Rama Raju Kanumuri, Abhisheak Sharma, Danxin Wang, Julie A Johnson

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical and translational science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Noor Ahmed NahidDepartment of Pharmacotherapy and Translational Research and Center for Pharmacogenomics and Precision Medicine, University of Florida College of Pharmacy, Gainesville, Florida, USA.ORCID 0000-0002-2190-7555
Siva Rama Raju KanumuriDepartment of Pharmaceutics, University of Florida College of Pharmacy, Gainesville, Florida, USA.ORCID 0000-0002-6087-6587
Abhisheak SharmaDepartment of Pharmaceutics, University of Florida College of Pharmacy, Gainesville, Florida, USA.ORCID 0000-0003-0553-4039
Danxin WangDepartment of Pharmacotherapy and Translational Research and Center for Pharmacogenomics and Precision Medicine, University of Florida College of Pharmacy, Gainesville, Florida, USA.ORCID 0000-0002-7134-3065
Julie A JohnsonDepartment of Pharmacotherapy and Translational Research and Center for Pharmacogenomics and Precision Medicine, University of Florida College of Pharmacy, Gainesville, Florida, USA.ORCID 0000-0001-9847-1932

Funding

Expression genetics of pharmacogenesR35GM140845 · NIGMS · UNIVERSITY OF FLORIDA · PI Danxin Wang · 2021 to 2026
$2.2M
NIGMS NIH HHS R35 GM140845
6 · The paper itself

Abstract

Tramadol, the 41st most prescribed drug in the United States in 2021 is a prodrug activated by CYP2D6, which is highly polymorphic. Previous studies showed enzyme-inhibitor affinity varied between different CYP2D6 allelic variants with dextromethorphan and atomoxetine metabolism. However, no study has compared tramadol metabolism in different CYP2D6 alleles with different CYP2D6 inhibitors. We hypothesize that the inhibitory effects of CYP2D6 inhibitors on CYP2D6-mediated tramadol metabolism are inhibitor- and CYP2D6-allele-specific. We performed comparative analyses of CYP2D6*1, CYP2D6*2, CYP2D6*10, and CYP2D6*17 using recombinant enzymes to metabolize tramadol to O-desmethyltramadol, measured via UPLC-MS/MS. The Michaelis constant (K

Indexed as

Analgesics, OpioidCytochrome P-450 CYP2D6Cytochrome P-450 CYP2D6 InhibitorsTramadolAllelesHumansAnalgesics, OpioidCytochrome P-450 CYP2D6Cytochrome P-450 CYP2D6 InhibitorsO-demethyltramadolTramadol

Identifiers

PMID39870079
PMCPMC11772017

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.