ArticleHuman vaccines & immunotherapeutics2025
Disease burden of influenza in Spain: A five-season study (2015-2020).
Article in Human vaccines & immunotherapeutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- The economic burden of seasonal influenza - China, 2010-2019.Human vaccines & immunotherapeutics · 2026Article
- Influenza Complications in Children: The Experience of a Children's Hospital in Romania and a Comparative Literature Review of Western and Eastern Studies.Diseases (Basel, Switzerland) · 2026Article
- Influenza Vaccination in Spain: Understanding the Impact of Suboptimal Coverage on Health, Society, and the Economy.Vaccines · 2026Review
- Article
- From methods to policy: a critical appraisal of the 2024 ECDC guidance on enhanced influenza vaccines.Frontiers in public health · 2026Article
- State-of-the-art of the high dose influenza vaccine in Spain.Frontiers in immunology · 2026Review
- [Recommendations on prevention and treatment of respiratory infections in institutionalised older people].Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia · 2025Review
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Authors and funding
13 authors.
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Abstract
Influenza accounts for 30% of the total morbidity and mortality in the European Union. However, the specific burden in different European countries is largely unknown, and more research is needed to ascertain the reality of this disease. In this retrospective study, we analyzed the burdens of hospitalization, intensive care unit (ICU) admission and in-hospital mortality in Spain over five seasons (2015-2020) via publicly available Minimum Basic Datasets (MDBS). The data revealed that influenza had a major impact in Spain, with approximately 29,000 hospitalizations, 2,200 ICU admissions, and 1,600 deaths each season. In this period, approximately 7.8% of those hospitalized required ICU admission, and 5.7% died in the hospital due to influenza, with wide differences in these parameters depending on the season due to the virological characteristics of the major circulating viruses. More than 60% of those hospitalized were over 65 years of age, and approximately 82% of those who died were elderly, demonstrating that the greatest burden of hospitalization and mortality is centered on this age group. The annual direct cost of influenza was approximately €128 million per season, with more than 80% of this cost centered on people over 45 years of age.
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