Evidence map›Paper›PMID 39869636›Full record

ArticlePLoS pathogens2025

Staphylococcus aureus blocks host autophagy through circSyk/miR-5106/Sik3 axis to promote progression of bone infection.

Zhihao Chen, Qiyuan Jin, Jinqi Zhong, Zonggang Xie, Qi Chen, Liubing Li, Jijie Li, Chenhao Zhao, Junfeng Wang, Xiaoying Tang and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PLoS pathogens, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Zhihao ChenDepartment of Orthopedics, The Second Affiliated Hospital of Soochow University, Suzhou, China.
Qiyuan JinDepartment of Clinical Laboratory, The Second Affiliated Hospital of Soochow University, Suzhou, China.
Jinqi ZhongDepartment of Clinical Laboratory, The Second Affiliated Hospital of Soochow University, Suzhou, China.
Zonggang XieDepartment of Orthopedics, The Second Affiliated Hospital of Soochow University, Suzhou, China.
Qi ChenDepartment of Clinical Laboratory, The Second Affiliated Hospital of Soochow University, Suzhou, China.
Liubing LiDepartment of Orthopedics, The Second Affiliated Hospital of Soochow University, Suzhou, China.
Jijie LiDepartment of Clinical Laboratory, The Second Affiliated Hospital of Soochow University, Suzhou, China.
Chenhao ZhaoDepartment of Clinical Laboratory, The Second Affiliated Hospital of Soochow University, Suzhou, China.
Junfeng WangDepartment of Clinical Laboratory, The Nuclear Industry 417 Hospital, Xi'an, China.
Xiaoying TangDepartment of Clinical Laboratory, The Second Affiliated Hospital of Soochow University, Suzhou, China.
Mingxiao HanDepartment of Clinical Laboratory, The Second Affiliated Hospital of Soochow University, Suzhou, China.
Ru LiDepartment of Clinical Laboratory, The Nuclear Industry 417 Hospital, Xi'an, China.
Ziyuan LiDepartment of Orthopedics, The Second Affiliated Hospital of Soochow University, Suzhou, China.
Zelei TongDepartment of Orthopedics, The Second Affiliated Hospital of Soochow University, Suzhou, China.
Min WangDepartment of Clinical Laboratory, The Second Affiliated Hospital of Soochow University, Suzhou, China.
Hong DuDepartment of Clinical Laboratory, The Second Affiliated Hospital of Soochow University, Suzhou, China.
Haifang ZhangDepartment of Clinical Laboratory, The Second Affiliated Hospital of Soochow University, Suzhou, China.ORCID 0009-0007-9146-1265

Funding

Discipline Construction of The Second Afliated Hospital of Soochow UniversityScientific Research Project Foundation of Xi’ an Health CommissionThe Pre-Research Foundation of The Nuclear Industry 417 HospitalThe Suzhou Health Talents Program
6 · The paper itself

Abstract

With the rapid increase in the number of implant operations, the incidence of bone infections has increased. Methicillin-resistant Staphylococcus aureus (S. aureus) and other emerging fully drug-resistant strains make the management of bone infections even more challenging. Bone infections are mainly caused by S. aureus and require extensive surgical intervention and long-term antibiotic therapy. The host autophagy response is critical to the elimination of S. aureus infections. In this study, we demonstrate that a circular RNA (circRNA), circSyk, is a potential biological target for the treatment of S. aureus-induced bone infection. Most importantly, S. aureus regulates circSyk to block autophagy and promote bone destruction via the circSyk/miR-5106/Sik3 axis in a nonclassical pathway, which is involved in the S. aureus infection process through a competitive endogenous RNA network. In summary, this study proposes a novel perspective on the immune escape of S. aureus in bone infections, based on circRNA.

Indexed as

AutophagyMicroRNAsRNA, CircularStaphylococcal InfectionsStaphylococcus aureusAnimalsDisease ProgressionHumansMiceMicroRNAsRNA, Circular

Identifiers

PMID39869636
PMCPMC11781720

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.