Evidence map›Paper›PMID 39869213›Full record

ArticleNeurochemical research2025

The Regulation of Messenger RNAs and Biological Pathways by Long Non-Coding RNAs and Circular RNAs in Ischemic Stroke.

Tian Xu, Mingfeng Tao, Yizhou Lin, Jiayuan Zhang, Ziyi Wang, Yongxin Li, Lingli Li, Jinlu An

Abstract read
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Article in Neurochemical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Tian XuDepartment of Neurology, Affiliated Hospital of Nantong University, 20 Xisi Road, Nantong, 226001, China. xutian84@163.com.
Mingfeng TaoDepartment of Neurology, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong, 226001, China.
Yizhou LinMedical School of Nantong University, Nantong, 226001, China.
Jiayuan ZhangDepartment of Neurology, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong, 226001, China.
Ziyi WangDepartment of Neurology, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong, 226001, China.
Yongxin LiDepartment of Neurology, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong, 226001, China.
Lingli LiDepartment of Neurology, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong, 226001, China.
Jinlu AnDepartment of Neurology, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong, 226001, China.

Funding

National Natural Science Foundation of China 82073627
6 · The paper itself

Abstract

Our aim was to evaluate the regulation of messenger RNAs (mRNAs) and biological pathways by long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) in ischemic stroke. We employed weighted gene co-expression network analysis (WGCNA) to construct two co-expression networks for mRNAs with circRNAs and lncRNAs, respectively, to investigate their association with ischemic stroke. We compared the overlap of mRNAs and biological pathways in the stroke-associated modules of the two networks. Furthermore, we validated the association of key non-coding RNAs with the risk of ischemic stroke and poor prognosis using quantitative real-time polymerase chain reaction. Ischemic stroke patients exhibited lower eigengene expression in the turquoise module associated with lncRNAs and mRNAs, as well as in the turquoise, red, and greenyellow modules associated with circRNAs and mRNAs in ischemic stroke. In the lncRNA-mRNA network and circRNA-mRNA network, we observed a significant overlap of the 5126 mRNAs (P < 0.001) and 51 biological pathways (P < 0.001), respectively. Among the ten key non-coding RNAs, lnc-TPRG1-AS1, lnc-GUK1, and hsa_circ_RELL1 were significantly increased (P < 0.05), while hsa_circ_ZBTB20 and hsa_circ_ERBB2 were significantly decreased (P < 0.05) in ischemic stroke. Additionally, ischemic stroke patients with poor functional outcome had significantly lower levels of hsa_circ_ZBTB20 and hsa_circ_ERBB2 compared to those with favorable prognosis (P < 0.05). Our findings suggest lncRNAs and circRNAs display similar biological functions in ischemic stroke. Key non-coding RNAs may be associated with the risk and clinical prognosis of ischemic stroke. These results warrant further validation in the future studies.

Indexed as

Ischemic StrokeRNA, CircularRNA, Long NoncodingRNA, MessengerFemaleGene Regulatory NetworksHumansMaleSignal TransductionRNA, CircularRNA, Long NoncodingRNA, MessengerBiological pathwayCircular RNAIschemic strokeLong non-coding RNAMessenger RNA

Identifiers

PMID39869213

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.