ArticleBrain structure & function2025
rsfMRI-based brain entropy is negatively correlated with gray matter volume and surface area.
Article in Brain structure & function, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Brain entropy as a biomarker of major depression in adolescents and young adults: insights from multimodal resting-state functional magentic resonance imaging.Psychoradiology · 2026Article
- Brain Entropy: Linking Brain Structure to Task Activation.bioRxiv : the preprint server for biology · 2025Article
- Chronic pain is associated with greater brain entropy in the prefrontal cortex.The journal of pain · 2025Article
- Normative Brain Entropy Across the Lifespan.bioRxiv : the preprint server for biology · 2025Article
- Resting state fMRI-based temporal coherence mapping.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- The link to steady-state oxidative metabolism and hemodynamics varies across rs-fMRI metrics: A whole-brain assessment using macrovascular correction.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Global brain connectivity: Test-retest stability and association with biological and neurocognitive variables.Journal of neuroscience methods · 2024Article
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Authors and funding
2 authors.
Funding
Abstract
The brain entropy (BEN) reflects the randomness of brain activity and is inversely related to its temporal coherence. In recent years, BEN has been found to be associated with a number of neurocognitive, biological, and sociodemographic variables such as fluid intelligence, age, sex, and education. However, evidence regarding the potential relationship between BEN and brain structure is still lacking. In this study, we use resting-state fMRI (rsfMRI) data to estimate BEN and investigate its associations with three structural brain metrics: gray matter volume (GMV), surface area (SA), and cortical thickness (CT). We performed separate analyses on BEN maps derived from four distinct rsfMRI runs, and used a voxelwise as well as a regions-of-interest (ROIs) approach. Our findings consistently showed that lower BEN was related to increased GMV and SA in the lateral frontal and temporal lobes, inferior parietal lobules, and precuneus. We hypothesize that lower BEN and higher SA might reflect higher brain reserve as well as increased information processing capacity.
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Registered trials
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