Evidence map›Paper›PMID 39869209›Full record

ArticleBrain structure & function2025

Decreases in frequency-dependent intrinsic activity of the default mode network are associated with depression and cognition in patients with postacute sequelae of SARS-CoV-2 infection.

Yao Wang, Ziwei Yang, Xiumei Zheng, Xiao Liang, Lin Wu, Chengsi Wu, Jiankun Dai, Yuan Cao, Xianjun Zeng, Meng Li and 1 more

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Article in Brain structure & function, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Yao WangDepartment of Radiology, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, 330006, Jiangxi Province, China.
Ziwei YangDepartment of Radiology, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, 330006, Jiangxi Province, China.
Xiumei ZhengDepartment of Radiology, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, 330006, Jiangxi Province, China.
Xiao LiangDepartment of Radiology, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, 330006, Jiangxi Province, China.
Lin WuDepartment of Radiology, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, 330006, Jiangxi Province, China.
Chengsi WuDepartment of Neurology, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, 330006, Jiangxi Province, China.
Jiankun DaiMR Research, GE Healthcare, Beijing, 100000, China.
Yuan CaoDepartment of Psychiatry and Psychotherapy, Jena University Hospital, Jena, Germany.
Xianjun ZengDepartment of Radiology, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, 330006, Jiangxi Province, China.
Meng LiDepartment of Psychiatry and Psychotherapy, Jena University Hospital, Jena, Germany. Meng.Li@med.uni-jena.de.
Fuqing ZhouDepartment of Radiology, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, 330006, Jiangxi Province, China. ndyfy02301@ncu.edu.cn.

Funding

Clinical Research Center For Medical Imaging In Jiangxi Province 20223BCG74001Jiangxi Province Double Thousand Talent Plan jxsq2023201039
6 · The paper itself

Abstract

A significant proportion of patients who have recovered from COVID-19 suffer from persistent symptoms, referred to as "post-acute sequelae of SARS-CoV-2 infection (PASC)". Abnormal brain intrinsic activity has been observed in PASC patients, but the patterns of frequency-dependent intrinsic activity in the PASC and non-PASC (recovered COVID-19 patients without persistent symptoms) groups and their association with neuropsychiatric sequelae remain unclear in PASC. Twenty-nine PASC patients, 27 non-PASC subjects, and 31 healthy controls (HCs) were recruited. The voxel-level fractional amplitude of low-frequency fluctuation (fALFF) was calculated in different frequency bands (typical frequency band: 0.01-0.10 Hz; slow 5: 0.01-0.023 Hz; slow 4: 0.023-0.073 Hz) to assess regional intrinsic activity patterns within different groups. Correlation analyses were performed to explore the associations between frequency-dependent alterations and clinical variables. Significant frequency-dependent alterations in intrinsic activity patterns were observed in both the PASC and non-PASC groups, primarily involving regions of the default mode network (DMN). The decreased fALFF values of the DMN in different frequency bands were associated with different symptoms in PASC. For example, decreased fALFF in the left precuneus in the typical frequency band was related to general attention impairment in PASC, whereas decreased fALFF in the left superior frontal gyrus appeared in non-PASC. The fALFF alterations in the left precuneus/posterior cingulate gyrus in the slow 5 band were also related to cognitive performance in PASC. Additionally, in the slow 4 band, decreased fALFF in the right angular gyrus was associated with depressive symptoms in the PASC. Our results may provide insights into the potential neural mechanisms underlying symptoms in PASC patients.

Indexed as

BrainCognitionCOVID-19Default Mode NetworkDepressionAdultBrain MappingFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedPost-Acute COVID-19 SyndromeSARS-CoV-2Cognitive performanceDefault mode networkDepressionIntrinsic brain activityPostacute sequelae of SARS-CoV-2 infection

Identifiers

PMID39869209

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.