Evidence map›Paper›PMID 39869205›Full record

ArticlePediatric nephrology (Berlin, Germany)2025

Thick skin and thicker arteries: case report on a rare cause of hypertension.

Georgie Mathew, Srinivasavaradan Govindarajan, Swathi Kiran Shiri, Deepthi Rv, Gurijala Phaneendra Rao, Indira Agarwal

Abstract readCase Reports
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In one paragraph

Article in Pediatric nephrology (Berlin, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Georgie MathewDepartment of Paediatric Nephrology, Christian Medical College, Vellore, India. georgie.mathew@cmcvellore.ac.in.ORCID 0000-0002-7670-4296
Srinivasavaradan GovindarajanDepartment of Paediatric Nephrology, Christian Medical College, Vellore, India.
Swathi Kiran ShiriDepartment of Paediatric Nephrology, Christian Medical College, Vellore, India.
Deepthi RvDepartment of Paediatric Nephrology, Christian Medical College, Vellore, India.
Gurijala Phaneendra RaoDepartment of Radiodiagnosis, Christian Medical College, Vellore, India.
Indira AgarwalDepartment of Paediatric Nephrology, Christian Medical College, Vellore, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Renovascular hypertension is the second leading cause of hypertension. Twenty-seven genes have been attributed to monogenic renovascular hypertension at present. We present a 15-year-old boy with facial dysmorphism, thick skin and renovascular hypertension with a novel gain-of-function variant in SMAD4 gene suggesting Myhre syndrome. Hypertension was controlled with three anti-hypertensive agents and vascular intervention is planned. It is characterized by a multisystem connective tissue disorder associated with progressive fibrosis of skin, cardiovascular, musculoskeletal, gastrointestinal and respiratory systems. This case highlights the need for recognizing syndromic features in children with renovascular hypertension.

Indexed as

Hypertension, RenovascularSkinSmad4 ProteinAdolescentAntihypertensive AgentsHumansMaleAntihypertensive AgentsSmad4 ProteinSMAD4 protein, humanAdolescentMyhre syndromeRenovascular hypertensionSMAD4 gene variant

Identifiers

PMID39869205

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.