ArticleACS macro letters2025
Hydration Effects Driving Network Remodeling in Hydrogels during Cyclic Loading.
Article in ACS macro letters, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
3 citing papers in PubMed.
- Hydration as a governing state variable in the mechanical and electrical response of decellularized extracellular matrix materials.Journal of materials science. Materials in medicine · 2026Article
- Primary biomolecular adsorption energetics of core-shell nanocomplexes: Implications for biological interactions.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Enhanced Mechanophore Activation in Hydrogel Networks Driven by Swollen Network Pretension.The journal of physical chemistry. B · 2025Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In complex networks and fluids such as the extracellular matrix, the mechanical properties are substantially affected by the movement of polymers both part of and entrapped in the network. As many cells are sensitive to the mechanical remodeling of their surroundings, it is important to appreciate how entrapped polymers may inhibit or facilitate remodeling in the network. Here, we explore a molecular-level understanding of network remodeling in a complex hydrogel environment through successive compressive loading and the role that noninteracting polymers may play in a dynamic network. We find that this is a highly localized and time-dependent effect, with one of the major driving factors of hydrogel matrix remodeling the interaction and movement of water within the network in calcium-cross-linked alginate. Our results suggest a more general mechanistic understanding of hydrogel remodeling, with implications for tissue transformations in disease, biomaterials, and food science formulation.
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Registered trials
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