ArticleImmunity, inflammation and disease2025
Blast-Overpressure Induced Modulation of PARP-SIRT-NRF2 Axis in Stress Signaling of Astrocytes and Microglia.
Article in Immunity, inflammation and disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Post-Translational Modifications in Traumatic Brain Injury: Decoding the Proteomic Landscape and Molecular Mechanisms of Secondary Injury.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Review
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Authors and funding
5 authors.
Funding
Abstract
backgroundThe pathomechanism of blast traumatic brain injury (TBI) and blunt TBI is different. In blast injury, evidence indicates that a single blast exposure can often manifest long-term neurological impairments. However, its pathomechanism is still elusive, and treatments have been symptomatic. Poly adenosine diphosphate (ADP) ribose polymerase-1 (PARP1) is implicated in the parthanatos and secondary neuroinflammation. Animal studies indicate the over-activation of PARP1 as a significant downstream event underlying the neurological sequelae of several traumatic and neurodegenerative disorders, irrespective of the mode of cell death. PARP over-activation forms ADP polymers on several nuclear proteins, known as trans-PARylation, by consuming nicotinamide adenine dinucleotide (NAD HYPOTHESIS: We recently established the implication of PARP1 following blast overpressure (BOP) and its differential response on astrocytes and microglial cells. We found that the inhibition of PARP is proven beneficial by attenuating oxidative stress. In this study, we hypothesized the involvement of the PARP1-SIRT-NRF2 axis following induced blast-induced PARP over-activation in glial cells for the manifestation of oxidative stress in BOP insults.
objectiveThe objective is to determine the downstream modulation of the PARP-SIRT-NRF2 axis and changes in ATP levels following blast exposure in astrocytes and microglia cell lines.
resultsAs a result of NAD
conclusionThis result shows that blast-induced PARP1 over-activation impacts the deacetylation activity of sirtuins and consequently impacts the regulation of antioxidant levels in astrocytes and microglia.
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