Evidence map›Paper›PMID 39868924›Full record

ArticleThyroid : official journal of the American Thyroid Association2025

Proteomic Profiling of Medullary Thyroid Cancer Identifies CAPN1 as a Key Regulator of NF1 and RET Fueled Growth.

Eshan Khan, Hannah Hylton, Neel Rajan, Stephanie J Bouley, Jalal K Siddiqui, Swetha Rajasekaran, Ganesh R Koshre, Hayden Storts, Anisley Valenciaga, Misbah Khan and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Thyroid : official journal of the American Thyroid Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Eshan KhanDepartment of Cancer Biology and Genetics, The Ohio State University, Columbus, Ohio, USA.
Hannah HyltonDepartment of Cancer Biology and Genetics, The Ohio State University, Columbus, Ohio, USA.
Neel RajanThe Ohio State University Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, USA.
Stephanie J BouleyCenter for Genomic Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.
Jalal K SiddiquiDepartment of Cancer Biology and Genetics, The Ohio State University, Columbus, Ohio, USA.
Swetha RajasekaranDepartment of Cancer Biology and Genetics, The Ohio State University, Columbus, Ohio, USA.
Ganesh R KoshreDepartment of Cancer Biology and Genetics, The Ohio State University, Columbus, Ohio, USA.
Hayden StortsDepartment of Cancer Biology and Genetics, The Ohio State University, Columbus, Ohio, USA.ORCID 0009-0004-1945-4536
Anisley ValenciagaThe Ohio State University Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, USA.
Misbah KhanDepartment of Cancer Biology and Genetics, The Ohio State University, Columbus, Ohio, USA.
Sandya LiyanarachchiThe Ohio State University Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, USA.
Francisco FernandezCenter for Genomic Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.
Xuguang ZhengThe Ohio State University Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, USA.
John PhayDivision of Surgical Oncology, Ohio State University Comprehensive Cancer Center and Ohio State University Wexner Medical Center, Columbus, Ohio, USA.ORCID 0000-0002-8482-2137
Priya H DedhiaDivision of Surgical Oncology, Ohio State University Comprehensive Cancer Center and Ohio State University Wexner Medical Center, Columbus, Ohio, USA.ORCID 0000-0002-1884-408X
Jing WangDepartment of Cancer Biology and Genetics, The Ohio State University, Columbus, Ohio, USA.ORCID 0009-0005-5145-1156
James A WalkerCenter for Genomic Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.
Matthew D RingelThe Ohio State University Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, USA.
Wayne O MilesDepartment of Cancer Biology and Genetics, The Ohio State University, Columbus, Ohio, USA.ORCID 0000-0002-2054-5206

Funding

Translational Therapeutics Research Program (TT)P30CA016058 · NCI · OHIO STATE UNIVERSITY · PI Daniel G. Stover · 1985 to 2026
$132.3M
The translation regulation of pro-apoptotic genesR01CA251753 · NCI · OHIO STATE UNIVERSITY · PI MILES, WAYNE · 2020 to 2024
$2.0M
Role of p21-activated kinases in thyroid cancerR01CA227847 · NCI · OHIO STATE UNIVERSITY · PI RINGEL, MATTHEW D · 2018 to 2022
$1.9M
NCI NIH HHS P30 CA016058NCI NIH HHS R01 CA227847NCI NIH HHS R01 CA251753
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

CalpainCarcinoma, NeuroendocrineNeurofibromin 1Proto-Oncogene Proteins c-retThyroid NeoplasmsAnimalsCell Line, TumorCell ProliferationFemaleGene Expression Regulation, NeoplasticHumansMiceMultiple Endocrine Neoplasia Type 2aPiperidinesProteomicsQuinazolinesCalpainCAPN1 protein, humanNeurofibromin 1NF1 protein, humanPiperidinesProto-Oncogene Proteins c-retQuinazolinesRET protein, humanvandetanibCAPN1medullary thyroid cancerNF1proteomicsRETselpercatinibvandetanib

Identifiers

PMID39868924
PMCPMC12394799

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.