Evidence map›Paper›PMID 39868890›Full record

ArticleJournal of cardiovascular electrophysiology2025

Predictors of Arrhythmia Recurrence After Cryoballoon Ablation for Persistent Atrial Fibrillation: A Sub-Analysis of the Cryo Global Registry.

K R Julian Chun, Christoph Stellbrink, Masato Murakami, Christian Drephal, Il-Young Oh, Kelly A van Bragt, Daniel Becker, Sylvain Anselme, Derick Todd, Krzysztof Kaczmarek and 1 more

Abstract readMulticenter Study
In one paragraph

Article in Journal of cardiovascular electrophysiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

K R Julian ChunCardioangiologisches Centrum Bethanien, Frankfurt, Germany.
Christoph StellbrinkUniversitat Bielefeld Medizinische Fakultat OWL, Bielefeld, Germany.
Masato MurakamiShonan Kamakura Sogo Byoin Nosocchu Shinryoka, Kamakura, Japan.
Christian DrephalSana Klinikum Lichtenberg, Berlin, Germany.
Il-Young OhSeoul National University Bundang Hospital, Seongnam, South Korea.
Kelly A van BragtMedtronic, Minneapolis, MN, United States.ORCID 0000-0003-4118-4291
Daniel BeckerMedtronic, Minneapolis, MN, United States.ORCID 0000-0001-8023-9246
Sylvain AnselmeMedtronic France SAS, Paris, France.
Derick ToddLiverpool Heart and Chest Hospital NHS Foundation Trust, Liverpool, UK.
Krzysztof KaczmarekUniwersytet Medyczny w Lodzi Klinika Kardiologii, Łódź, Poland.
Junichi NittaSakakibara Kinen Byoin, Fuchu, Japan.

Funding

The study was supported by the Medtronic.
6 · The paper itself

Abstract

introductionFreedom from recurrences of atrial tachyarrhythmia (ATA) is suboptimal after pulmonary vein isolation (PVI) in patients with persistent atrial fibrillation (PsAF). This sub-analysis from the Cryo Global Registry sought to investigate predictors of ablation success after PVI using cryoballoon ablation (CBA) for PsAF. METHODS AND

resultsATA recurrence was defined as ≥ 30 s recurrence of atrial fibrillation, atrial flutter or atrial tachycardia after a 90-day blanking period and through 12-months. Univariate and multivariable Cox regression analysis (with ATA recurrence as an endpoint) was performed to identify CBA responders. PsAF patients (N = 882) were on average 63.9 ± 11.3 years old (69.2% male), and freedom from ATA recurrence was 79.7% (76.8%-82.2%). Longer elapsed time from PsAF diagnosis to ablation (hazard ratio [HR] 1.07 (95% confidence interval [CI]: 1.03-1.11); p = 0.002) and a larger number of previously failed antiarrhythmic drugs (HR 1.39 (95% CI: 1.13-1.70); p < 0.002) were shown to be independent predictors of ATA recurrence in a multivariate model which included 703 evaluated patients.

conclusionThese real-world results provide important insights to guide referral of PsAF patients, including the benefits of earlier treatment via CBA.

Indexed as

Atrial FibrillationCryosurgeryPulmonary VeinsTachycardia, SupraventricularAction PotentialsAgedFemaleHeart RateHumansMaleMiddle AgedMultivariate AnalysisProportional Hazards ModelsRecurrenceRegistriesRisk Factorscatheter ablationcryoballoonpersistent atrial fibrillationpredictorsregistry

Identifiers

PMID39868890
PMCPMC11984336

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.