ArticleJournal of internal medicine2025
Opportunistic assessment of steatotic liver disease in lung cancer screening eligible individuals.
Article in Journal of internal medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Uncovering hidden HCV infections in adults over 55: reflex testing and insights for opportunistic screening in a tertiary care setting.Archives of public health = Archives belges de sante publique · 2026Article
- Opportunistic assessment of steatotic liver disease in lung cancer screening eligible individuals.Journal of internal medicine · 2025Article
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Authors and funding
8 authors.
Funding
Abstract
backgroundSteatotic liver disease (SLD) is a potentially reversible condition but often goes unnoticed with the risk for end-stage liver disease. PURPOSE: To opportunistically estimate SLD on lung screening chest computed tomography (CT) and investigate its prognostic value in heavy smokers participating in the National Lung Screening Trial (NLST). MATERIAL AND
methodsWe used a deep learning model to segment the liver on non-contrast-enhanced chest CT scans of 19,774 NLST participants (age 61.4 ± 5.0 years; 41.2% female) at baseline and on the 1-year follow-up scan if no cancer was detected. SLD was defined as hepatic fat fraction (HFF) ≥5% derived from Hounsfield unit measures of the segmented liver. Participants with SLD were categorized as lean (body mass index [BMI] < 25 kg/m
resultsThere were 5.1% (1000/19,760) all-cause deaths over a median follow-up of 6 (range, 0.8-6) years. At baseline, SLD was associated with increased mortality in lean but not in overweight/obese participants as compared to participants without SLD (hazard ratio [HR] adjusted for risk factors: 1.93 [95% confidence interval 1.52-2.45]; p = 0.001). Individuals with an increase in HFF within 1 year had a significantly worse outcome than participants with stable HFF (HR adjusted for risk factors: 1.29 [1.01-1.65]; p = 0.04).
conclusionSLD is an independent predictor for long-term mortality in heavy smokers beyond known clinical risk factors.
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