ArticleCell and tissue research1985
Uptake of horseradish peroxidase by bone cells during endochondral bone development.
Article in Cell and tissue research, 1985. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed, 25 citations in OpenAlex.
- Osteocytic Osteolysis in PTH-treated Wild-type andThe journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2020Article
- Three-dimensional ultrastructure of osteocytes assessed by focused ion beam-scanning electron microscopy (FIB-SEM).Histochemistry and cell biology · 2018Article
- A histological assessment on the distribution of the osteocytic lacunar canalicular system using silver staining.Journal of bone and mineral metabolism · 2007Article
- Diffusion of exchangeable water in cortical bone studied by nuclear magnetic resonance.Biophysical journal · 2002Article
- Expression of vacuolar H(+)-ATPase in osteoclasts and its role in resorption.Cell and tissue research · 1994Article
- Phagocytosis of different matrix components by different cell types at bone-forming sites in cultured mouse calvariae.Cell and tissue research · 1986Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To investigate the mechanisms whereby bone cells absorb organic bone-matrix components during endochondral bone development, rat humeri were examined, employing horseradish peroxidase as a soluble protein tracer. Intravenously-injected peroxidase filled the osteoid layer and penetrated into the osteocyte lacunae and canaliculi, but did not enter the mineralized bone matrix. Whereas osteocytes rarely took up exogenous peroxidase, osteoblasts and osteoclasts actively endocytosed peroxidase in pinocytotic coated vesicles, tubular structures, and vacuoles. They also formed endocytotic vacuoles containing peroxidase in the Golgi area. The Golgi apparatus and dense bodies of these bone cells were, however, free of reaction products. Osteoclast ruffled borders were responsible for peroxidase absorption. In the osteoblast, osteocyte and osteoclast, endogenous peroxidatic reaction was detected only in mitochondria and not in other membrane-bounded vesicles and bodies. These results strongly suggest that both osteoblasts and osteoclasts participate in the resorption of bone-matrix organic components during bone remodelling.
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