Evidence map›Paper›PMID 39868794›Full record

ArticleAntimicrobial agents and chemotherapy2025

Molecular epidemiology of β-lactamases in ceftriaxone-resistant Enterobacterales bloodstream infections in the mid-Atlantic United States.

Dariusz A Hareza, Yehudit Bergman, Emily Jacobs, Jennifer Lu, Nancy D Hanson, Rick Conzemius, Sara E Cosgrove, Anthony D Harris, Patricia J Simner, Pranita D Tamma

Abstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. AMRrounds: Metallo-β-lactamase-producingJAC-antimicrobial resistance · 2025
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Dariusz A HarezaDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Yehudit BergmanDepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Emily JacobsDepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Jennifer LuDepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Nancy D HansonDepartment of Microbiology and Immunology, Creighton School of Medicine, Omaha, Nebraska, USA.
Rick ConzemiusAres Genetics, Vienna, Austria.
Sara E CosgroveDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Anthony D HarrisDepartment of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Patricia J Simner *Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.ORCID 0000-0001-6134-151X
Pranita D Tamma *Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.ORCID 0000-0002-4143-6324

Funding

Antibacterial Resistance Leadership Group (ARLG)UM1AI104681 · NIAID · DUKE UNIVERSITY · PI Vance G. Fowler, Henry F HENRY CHAMBERS · 2013 to 2026
$180.8M
RESEARCH TRAINING IN MICROBIAL DISEASEST32AI007291 · NIAID · JOHNS HOPKINS UNIVERSITY · PI JOEL N BLANKSON, Sara Elizabeth Cosgrove · 1986 to 2026
$9.1M
Identifying Optimal Antibiotic Treatment for Non-CTX-M-Producing ESBL Bloodstream InfectionsR21AI173475 · NIAID · JOHNS HOPKINS UNIVERSITY · PI COSGROVE, SARA ELIZABETH, TAMMA, PRANITA · 2024 to 2025
$450k
HHS | National Institutes of Health (NIH) R21AI173475NCEZID CDC HHS U54 CK000617NIAID NIH HHS R21 AI173475NIAID NIH HHS T32 AI007291NIAID NIH HHS UM1 AI104681
6 · The paper itself

Abstract

Ceftriaxone-resistant Enterobacterales remain a public health threat; contemporary data investigating their molecular epidemiology are limited. Five hundred consecutive ceftriaxone-resistant (MIC ≥ 4 µg/mL) Enterobacterales bloodstream isolates were collected between 2018 and 2022 from three Maryland hospitals. Broth microdilution confirmed antibiotic susceptibilities. Whole-genome sequencing identified extended-spectrum β-lactamase (ESBL) and

Indexed as

Anti-Bacterial Agentsbeta-LactamasesCeftriaxoneEnterobacteriaceaeEnterobacteriaceae InfectionsBacterial ProteinsEscherichia coliHumansMicrobial Sensitivity TestsMolecular EpidemiologyPlasmidsWhole Genome SequencingAmpC beta-lactamasesAnti-Bacterial AgentsBacterial Proteinsbeta-LactamasesCeftriaxoneampCCMYCTX-MDHAECESBLsSHV

Identifiers

PMID39868794
PMCPMC11881560

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.