Evidence map›Paper›PMID 39868786›Full record

ArticleMicrobiology spectrum2025

Morgan J Engelhart, Orion D Brock, Jessica M Till, Robert W P Glowacki, Jason W Cantwell, David J Clarke, Darryl A Wesener, Philip P Ahern

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Microbiology spectrum, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Morgan J EngelhartDepartment of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA.
Orion D BrockDepartment of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA.
Jessica M TillDepartment of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA.
Robert W P GlowackiDepartment of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA.
Jason W CantwellDepartment of Microbiology, The Ohio State University, Columbus, Ohio, USA.
David J ClarkeSchool of Microbiology and APC Microbiome Ireland, University College Cork, Cork, Ireland.ORCID 0000-0001-9082-0501
Darryl A WesenerDepartment of Microbiology, The Ohio State University, Columbus, Ohio, USA.
Philip P AhernDepartment of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA.ORCID 0000-0002-2083-3224

Funding

Unraveling strain-level variation in the induction of anti-inflammatory responses in the intestineR01DK126772 · NIDDK · CLEVELAND CLINIC LERNER COM-CWRU · PI AHERN, PHILIP PATRICK · 2021 to 2025
$2.4M
Human gut bacterial cell surface polysaccharides as a microbial nutrient source and target of immunoregulatory proteins shape gut microbiota structure and functionR00AT011374 · NCCIH · OHIO STATE UNIVERSITY · PI WESENER, DARRYL A · 2023 to 2025
$707k
HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) R01DK126772NCCIH NIH HHS R00 AT011374NIDDK NIH HHS R01 DK126772Science Foundation Ireland (SFI) 12/IP/1493
6 · The paper itself

Abstract

The intestine is home to a complex immune system that is engaged in mutualistic interactions with the microbiome that maintain intestinal homeostasis. A variety of immune-derived anti-inflammatory mediators have been uncovered and shown to be critical for maintaining these beneficial immune-microbiome relationships. Notably, the gut microbiome actively invokes the induction of anti-inflammatory pathways that limit the development of microbiome-targeted inflammatory immune responses. Despite the importance of this microbiome-driven immunomodulation, detailed knowledge of the microbial factors that promote these responses remains limited. We have previously established that the gut symbiont IMPORTANCE: Intestinal homeostasis requires the establishment of peaceful interactions between the gut microbiome and the intestinal immune system. Members of the gut microbiome, like the symbiont

Indexed as

Bacterial ProteinsBacteroides thetaiotaomicronInterleukin-10AnimalsCell LineGastrointestinal MicrobiomeHumansToll-Like Receptor 2Bacterial ProteinsIL10 protein, humanInterleukin-10TLR2 protein, humanToll-Like Receptor 2anti-inflammatorygut microbiomeimmune regulation

Identifiers

PMID39868786
PMCPMC11878027

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.