Evidence map›Paper›PMID 39868751›Full record

ArticleESC heart failure2023

Prevalence of transthyretin amyloidosis among heart failure patients with preserved ejection fraction in Japan.

Takanori Naito, Kazufumi Nakamura, Yukio Abe, Hiroyuki Watanabe, Satoru Sakuragi, Yusuke Katayama, Hajime Kihara, Atsutaka Okizaki, Yusuke Kawai, Masaki Yoshikawa and 6 more

Abstract read
In one paragraph

Article in ESC heart failure, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Guideline
  2. Diagnostic Performance Evaluation of Clinical and Artificial Intelligence Risk Models in Patients Referred for Cardiac Amyloidosis Testing.Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography · 2026
    Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. The Progressive Cardiac Uptake ofInternal medicine (Tokyo, Japan) · 2026
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Observational
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Molecular Research on Amyloidosis.International journal of molecular sciences · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Takanori NaitoDepartment of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama, 700-8558, Japan.
Kazufumi NakamuraDepartment of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama, 700-8558, Japan.ORCID https://orcid.org/0000-0001-8845-3626
Yukio AbeDepartment of Cardiology, Osaka City General Hospital, Osaka, Japan.
Hiroyuki WatanabeDepartment of Cardiovascular Medicine, Tokyo Bay Urayasu Ichikawa Medical Center, Urayasu, Japan.
Satoru SakuragiDepartment of Cardiovascular Medicine, National Hospital Organization Iwakuni Clinical Center, Iwakuni, Japan.
Yusuke KatayamaDepartment of Cardiovascular Medicine, National Hospital Organization Iwakuni Clinical Center, Iwakuni, Japan.
Hajime KiharaDepartment of Internal Medicine, Kihara Cardiovascular Clinic, Asahikawa, Japan.
Atsutaka OkizakiDepartment of Radiology, Asahikawa Medical University, Asahikawa, Japan.
Yusuke KawaiDepartment of Cardiovascular Medicine, Okayama City Hospital, Okayama, Japan.
Masaki YoshikawaDepartment of Cardiovascular Medicine, Fukuyama City Hospital, Fukuyama, Japan.
Atsushi TakaishiDepartment of Cardiology, Mitoyo General Hospital, Kanonji, Japan.
Hideki FujioDepartment of Cardiovascular Medicine, Japanese Red Cross Society Himeji Hospital, Himeji, Japan.
Hiroaki OtsukaDepartment of Cardiovascular Medicine, National Hospital Organization Iwakuni Clinical Center, Iwakuni, Japan.
Soichiro OguraDepartment of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama, 700-8558, Japan.
Hiroshi ItoDepartment of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama, 700-8558, Japan.
ATTR‐HFpEF registry investigators

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsHeart failure with preserved ejection fraction (HFpEF), which is caused by wide various conditions, has become a major public health problem. Transthyretin amyloid cardiomyopathy (ATTR-CM), which is thought to be an underdiagnosed disease, can cause HFpEF. Non-invasive diagnosis using METHODS AND

resultsThis study was a multicentre, prospective, observational study conducted in Japan. We enrolled 373 patients with HFpEF [left ventricular (LV) ejection fraction ≥50%] aged ≥65 years who were admitted to the department of cardiology from September 2018 to January 2022. A

conclusionsATTR-CM is an underdiagnosed disease with a significant prevalence in Japanese patients with HFpEF. This study showed that results of examinations for ATTR-CM patients appear to be worse than those for non-ATTR-CM patients, but clinical severities of heart failure as assessed by the NYHA functional classification are similar in ATTR-CM and non-ATTR-CM patients, and the clinical overlap between ATTR-CM and non-ATTR-CM is high.

Indexed as

Heart failureLeft ventricular hypertrophyScintigraphyTransthyretin amyloidosis

Identifiers

PMID39868751
PMCPMC10192249

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.