Evidence map›Paper›PMID 39868746›Full record

ArticleThe American journal of sports medicine2025

Association Between Patient Characteristics and the Depth of Microvascular Penetration Into the Adult Human Meniscus.

Thies J N van der Lelij, Peter van Schie, Amber Weekhout, Marta Fiocco, Roelina Munnik-Hagewoud, Stijn Keereweer, Hans Marten Hazelbag, Ewoud R A van Arkel, Pieter B A A van Driel

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Article in The American journal of sports medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Thies J N van der LelijDepartment of Orthopaedics, Leiden University Medical Center, Leiden, The Netherlands.ORCID 0000-0003-0638-6568
Peter van SchieDepartment of Orthopaedics, Leiden University Medical Center, Leiden, The Netherlands.
Amber WeekhoutDepartment of Orthopaedics, Leiden University Medical Center, Leiden, The Netherlands.
Marta FioccoMathematical Institute Leiden University, Leiden, The Netherlands.
Roelina Munnik-HagewoudDepartment of Orthopaedics, Isala Hospital, Zwolle, The Netherlands.
Stijn KeereweerDepartment of Otorhinolaryngology, Erasmus Medical Center, Rotterdam, the Netherlands.
Hans Marten HazelbagDepartment of Pathology, Haaglanden Medical Center, The Hague, The Netherlands.
Ewoud R A van ArkelDepartment of Orthopaedics, Haaglanden Medical Center, The Hague, The Netherlands.
Pieter B A A van DrielDepartment of Orthopaedics, Isala Hospital, Zwolle, The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCurrent knowledge on the microvascular anatomy of adult human menisci is based on cadaveric studies. However, considerable interindividual variation in meniscal microvascularization has been reported in recent studies with small sample sizes. PURPOSE: To assess the association between patient characteristics and the depth of microvascularization of the meniscus. STUDY

designDescriptive laboratory study.

methodsMenisci from 174 patients who received total knee replacement between March 2021 and December 2023 were collected. A total of 174 lateral and 102 medial menisci were included. Three sections were made from each meniscus: the anterior horn, midbody, and posterior horn. Immunohistochemical staining (CD-31) was used to visualize the microvasculature. The 4 primary outcome measures were the correlation between the depth of microvascular penetration into the lateral meniscus (0%-100%) and (1) age, (2) smoking, (3) degree of osteoarthritis, and (4) history of cardiovascular disease. To account for repeated measurements within each patient, a linear mixed-effects model was estimated to study the association between microvascularization and the patient's characteristics previously introduced.

resultsThe depth of vascular penetration ranged from 0% to 78% into the lateral menisci and from 0% to 67% into the medial menisci. No significant correlations were found between age, smoking, degree of osteoarthritis, or history of cardiovascular disease and the degree of vascular penetration into the lateral meniscus. The linear mixed-effects model analysis, adjusted for location within the meniscus (anterior horn, midbody, or posterior horn) and meniscal side (lateral or medial), showed no significant associations between the same patient characteristics and meniscal microvascularization.

conclusionThe degree of microvascular penetration into the meniscus has a wide range among adults >50 years. However, the depth of microvascularization was not associated with age, smoking, degree of osteoarthritis, or history of cardiovascular disease. CLINICAL RELEVANCE: Because no associations were found between depth of microvascular penetration into the meniscus and patient characteristics, the latter cannot be used to estimate the vascular status of a meniscal tear in clinical practice.

Indexed as

Menisci, TibialMicrovesselsAdultAgedAged, 80 and overAge FactorsArthroplasty, Replacement, KneeCardiovascular DiseasesFemaleHumansMaleMiddle AgedOsteoarthritis, KneeSmokingblood supplymeniscal healingmeniscal tearmeniscusvascularization

Identifiers

PMID39868746
PMCPMC11874502

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.