Evidence map›Paper›PMID 39868624›Full record

SynthesisBiomarkers in medicine2025

HOTAIR expression as a biomarker in glioblastoma multiforme: a comprehensive meta-analysis of current evidence.

Arefeh Bahranian, Mehdi Koshki, Fargol Farahmandi, Kourosh Eftekharian, Samaneh Hemmati, Mahboobe Sattari, Alireza Zali, Ghodratollah Panahi

Abstract readMeta-AnalysisReview
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In one paragraph

Synthesis in Biomarkers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Arefeh BahranianSchool of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Mehdi KoshkiDepartment of Clinical Biochemistry, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran.
Fargol FarahmandiSchool of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Kourosh EftekharianDepartment of Otolaryngology, Head and Neck Surgery, Stanford University, Stanford, CA, USA.
Samaneh HemmatiDepartment of Clinical Biochemistry, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Mahboobe SattariDepartment of Clinical Biochemistry, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Alireza ZaliFunctional Neurosurgery Research Center, Shohada Tajrish Comprehensive Neurosurgical Center of Excellence, Shahid Beheshti University of Medical Sciences, Tehran, Iran.ORCID 0000-0002-9600-1520
Ghodratollah PanahiDepartment of Clinical Biochemistry, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.ORCID 0000-0001-8338-4633

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeGlioblastoma multiforme (GBM) is an aggressive brain tumor. This meta-analysis investigates the association between HOTAIR expression levels and GBM.

methodsWe searched the literature for studies on HOTAIR expression in GBM patients. A meta-analysis of nine studies assessed standardized mean difference (SMD) and 95% confidence intervals (CIs) using a random-effects model. Subgroup analyses were performed based on sample source, country, and study design. Additionally, we conducted meta-regression and publication bias analyses.

resultsThe meta-analysis found a significant positive association between elevated HOTAIR expression and GBM (SMD = 8.3, 95% CI 5.8-10.8,

conclusionThis analysis confirms the significant link between HOTAIR expression and GBM, highlighting HOTAIR as a potential therapeutic target and biomarker. Further research is necessary to clarify the biological mechanisms involved in this association.

Indexed as

Biomarkers, TumorBrain NeoplasmsGlioblastomaRNA, Long NoncodingGene Expression Regulation, NeoplasticHumansBiomarkers, TumorHOTAIR long untranslated RNA, humanRNA, Long NoncodingbiomarkerGlioblastoma multiformeHOTAIRlong non-coding RNAmeta-analysis

Identifiers

PMID39868624
PMCPMC11834459

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.