Evidence map›Paper›PMID 39868607›Full record

SynthesisJournal of the American Geriatrics Society2025

Medication Use Quality and Safety in Older Adults: 2023 Update.

Laura A Hart, Su Vo, Joseph T Hanlon, Kenneth E Schmader, Shelly L Gray

Abstract readSystematic Review
In one paragraph

Synthesis in Journal of the American Geriatrics Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Laura A HartSchool of Pharmacy, University of Washington, Seattle, Washington, USA.
Su VoSchool of Pharmacy, University of Washington, Seattle, Washington, USA.
Joseph T HanlonGeriatric Research, Education, and Clinical Center, Veterans Affairs Pittsburgh Healthcare System, Pittsburgh, Pennsylvania, USA.
Kenneth E SchmaderDepartment of Medicine (Geriatrics), School of Medicine, Duke University Medical Center, Durham, North Carolina, USA.
Shelly L GraySchool of Pharmacy, University of Washington, Seattle, Washington, USA.

Funding

Translational pharmacoepidemiology: neuroprotection and neurotoxicity of antihypertensives and strong anticholinergicsU19AG066567 · NIA · KAISER FOUNDATION RESEARCH INSTITUTE · PI Paul K Crane, Andrea Z. LaCroix · 2021 to 2026
$80.4M
Resource Core 3 - Metabolomics CoreP30AG028716 · NIA · DUKE UNIVERSITY · PI Virginia B Kraus · 2006 to 2026
$24.6M
Duke Claude D. Pepper Older Americans Independence Center, Duke Aging Center, Duke UniversityHealth Services Research and Development IIR HX002798HSRD VA I01 HX002798NIA NIH HHS P30 AG028716NIA NIH HHS P30AG028716NIA NIH HHS R01 AG07005NIA NIH HHS U19 AG066567NIA NIH HHS U19AG066567
6 · The paper itself

Abstract

Improving the quality of medication use and medication safety are important priorities for healthcare providers who care for older adults. The objective of this article was to identify four exemplary articles with this focus in 2023. We selected high-quality studies that advanced this field of research. The chosen articles cover domains related to deprescribing/discontinuation, optimizing medication use, medication safety/adverse drug events, and other. The first study was a randomized clinical trial evaluating the efficacy of the patient-centered Shed-MEDS deprescribing intervention among older adults transitioning from the hospital to postacute care facilities (domain: deprescribing/discontinuation). The second study, a retrospective cohort study among Medicare beneficiaries, described the phenomenon of a prescribing cascade relic and evaluated continued potassium use after discontinuation of a loop diuretic (domain: optimizing medication use). The third study was a systematic review and meta-analysis describing the prevalence of drug-drug interactions among community-dwelling older adults (domain: other). Lastly, the fourth study was a retrospective cohort study among Medicare beneficiaries that evaluated concurrent gabapentin and opioid use and risk of mortality (domain: medication safety). Collectively, this review succinctly highlights pertinent topics related to promoting safe use of medications and promotes awareness of optimizing older adults' medication regimens.

Indexed as

DeprescriptionsDrug-Related Side Effects and Adverse ReactionsPatient SafetyAgedAged, 80 and overDrug InteractionsHumansRetrospective StudiesUnited Statesageddeprescribinginappropriate prescribingmedication‐related problemspolypharmacy

Identifiers

PMID39868607
PMCPMC12215870

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.