Evidence map›Paper›PMID 39868520›Full record

ArticleJournal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale

The Economic Burden of Management of Pituitary Adenomas: A Propensity-Score-Matched Cost Analysis.

Lisa Caulley, Andrea Lasso, Brandon Zagorski, Andrew S Wilton, Refik Saskin, Nick Sahlollbey, Jeanne M Séguin, Kednapa Thavorn, Mary-Anne Doyle, Janine Malcolm and 4 more

Abstract read
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In one paragraph

Article in Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Lisa CaulleyDepartment of Otolaryngology-Head and Neck Surgery, University of Ottawa, Ottawa, ON, Canada.ORCID 0000-0002-9661-4634
Andrea LassoClinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada.ORCID 0000-0002-9552-264X
Brandon ZagorskiICES, Toronto, ON, Canada.
Andrew S WiltonICES, Toronto, ON, Canada.
Refik SaskinICES, Toronto, ON, Canada.
Nick SahlollbeyDepartment of Undergraduate Medicine, University of Ottawa, Ottawa, ON, Canada.ORCID 0009-0007-5864-0712
Jeanne M SéguinDepartment of Undergraduate Medicine, University of Ottawa, Ottawa, ON, Canada.
Kednapa ThavornClinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada.
Mary-Anne DoyleClinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada.
Janine MalcolmClinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada.
Fahad AlkherayfClinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada.
Stephanie Johnson-ObasekiDepartment of Otolaryngology-Head and Neck Surgery, University of Ottawa, Ottawa, ON, Canada.
David SchrammDepartment of Otolaryngology-Head and Neck Surgery, University of Ottawa, Ottawa, ON, Canada.
Shaun KiltyDepartment of Otolaryngology-Head and Neck Surgery, University of Ottawa, Ottawa, ON, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

importancePituitary adenomas (PAs) present a notable economic burden on healthcare systems due to their management's reliance on multimodal, often costly interventions.

objectiveTo determine total and relative healthcare costs for PAs at Ontario-based institutions.

designA retrospective, propensity-score-matched cohort analysis.

settingOntario, Canada, encompassing public healthcare facilities and covering costs over a 6-year study period.

participantsAdults diagnosed with PA (n = 1675) between April 1, 2013, and March 31, 2019, compared to a general population cohort and a hospitalized control cohort matched on demographics and health factors. INTERVENTION/EXPOSURES: Analysis of healthcare cost components (inpatient, outpatient, and diagnostic services) and cost trajectories postsurgery for PAs.

main outcome measuresPrimary outcome was total annualized healthcare costs for patients with PA relative to the general and hospitalized cohorts. Relative costs were estimated using a negative binomial regression model.

resultsOf 1675 patients with PA, total annualized costs were $49,992. Highest total costs were associated with inpatient hospitalization ($24,796) and physician services/diagnostic evaluations ($20,075). After propensity score matching, patients with PA had 12.7 times higher costs [95% confidence interval (CI) (10.9, 14.8),

conclusionsThis study provided a comprehensive assessment of the economic burden of PAs on the publicly-funded healthcare system. Patients with PA had higher annualized total costs across all observed time periods compared to the general population and lower annualized total costs compared to patients admitted to a surgical ward. RELEVANCE: This study highlights the financial impact of PA management on healthcare resources and provides a basis for future research aimed at cost-efficiency improvements in long-term PA care.

Indexed as

AdenomaCost of IllnessHealth Care CostsPituitary NeoplasmsAdultAgedCosts and Cost AnalysisFemaleHospitalizationHumansMaleMiddle AgedOntarioPropensity ScoreRetrospective Studiesendonasalendoscopic surgeryepidemiologyfollow-up studiespituitary neoplasmspropensity scoretranssphenoidal

Identifiers

PMID39868520
PMCPMC11770705

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.