Evidence map›Paper›PMID 39868446›Full record

ArticleProblemy endokrinologii2024

[Metastatic pheochromocytoma in multiple endocrine neoplasia type 2A].

D V Rebrova, V F Rusakov, L M Krasnov, E A Fedorov, I K Chinchuk, N V Vorokhobina, S S Shikhmagomedov, A A Semenov, R A Chernikov, I V Sleptsov and 2 more

Abstract readCase ReportsEnglish Abstract
PubMed Full text at PMC Publisher
In one paragraph

Article in Problemy endokrinologii, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

D V RebrovaSaint Petersburg State University, Saint Petersburg State University Hospital.
V F RusakovSaint Petersburg State University, Saint Petersburg State University Hospital.
L M KrasnovSaint Petersburg State University, Saint Petersburg State University Hospital.
E A FedorovSaint Petersburg State University, Saint Petersburg State University Hospital.
I K ChinchukSaint Petersburg State University, Saint Petersburg State University Hospital.
N V VorokhobinaNorth-Western State Medical University n.a. I.I. Mechnikov.
S S ShikhmagomedovSaint Petersburg State University, Saint Petersburg State University Hospital.
A A SemenovSaint Petersburg State University, Saint Petersburg State University Hospital.
R A ChernikovSaint Petersburg State University, Saint Petersburg State University Hospital.
I V SleptsovSaint Petersburg State University, Saint Petersburg State University Hospital.
G I GavtonNational Medical Research Center of Oncology n.a. N.N. Petrov.
E N ImyanitovNational Medical Research Center of Oncology n.a. N.N. Petrov.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pheochromocytoma (PHEO) currently is considered to be malignant due to metastatic potential. One of the most common familial forms of PHEO is multiple endocrine neoplasia syndrome (MEN) type 2. The penetrance of PHEO in MEN2 syndrome is up to 50% of cases. It may be one- or two-sided, but metastases occur extremely rare. The fact that in majority of cases of MEN2 syndrome the source of distant metastases is medullary thyroid carcinoma (MTC) complicates differential diagnosis in case of PHEO metastasis.Isolated cases of PHEO with metastases to the lymph nodes, lungs, liver, bones, brain in MEN2 patients were described. In the available literature, we have found a description of 31 cases of metastatic PHEO in MEN2 syndrome. The available data of those cases is presented as a table in the article.We present a description of a 40-year-old woman with MEN2A syndrome (mutation of the RET proto-oncogene p.Cys634Tyr), with a history of twice-performed surgical treatment of MTC, with daily crises of arterial hypertension accompanied by vegetative symptoms, with a giant bilateral PHEO (up to 200 m on the right and up to 150 mm on the left) with synchronous large metastasis (up to 50 mm) into the pubic bone with the destruction. The patient underwent several surgeries: bilateral adrenalectomy, then a bilateral revision of the neck, removal of the right upper and right lower parathyroid glands, residual thyroid tissue, then resection of the right pubic bone with a tumor.

Indexed as

Adrenal Gland NeoplasmsMultiple Endocrine Neoplasia Type 2aPheochromocytomaAdultFemaleHumansProto-Oncogene MasProto-Oncogene Proteins c-retThyroid NeoplasmsMAS1 protein, humanProto-Oncogene MasProto-Oncogene Proteins c-ret

Identifiers

PMID39868446
PMCPMC11775673

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