Evidence map›Paper›PMID 39868354›Full record

ArticleClinical Medicine Insights. Oncology2025

Modifiable Risk Factors Including Self-Perceived Stress for Breast Cancer in Hong Kong: A Case-Control Study of 10 757 Subject.

Winnie Yeo, Lok-Wa Yuen, Kelvin Kam-Fai Tsoi, Emily Ying-Yang Chan, Carol C Kwok, Inda Soong, Ting-Ying Ng, Joanne Chiu, Miranda Chan, Sharon Wing-Wai Chan and 6 more

Abstract read
In one paragraph

Article in Clinical Medicine Insights. Oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Winnie YeoDepartment of Clinical Oncology, Prince of Wales Hospital, Faculty of Medicine, The Chinese University of Hong Kong, Sha Tin, Hong Kong.ORCID https://orcid.org/0000-0002-0863-8469
Lok-Wa YuenDepartment of Surgery, Hong Kong Breast Cancer Foundation, North Point, Hong Kong.
Kelvin Kam-Fai TsoiDepartment of Clinical Research and Biostatistics, Jockey Club School of Public Health and Primary Care, Prince of Wales Hospital, Sha Tin, Hong Kong.
Emily Ying-Yang ChanDepartment of Clinical Research and Biostatistics, Jockey Club School of Public Health and Primary Care, Prince of Wales Hospital, Sha Tin, Hong Kong.
Carol C KwokDepartment of Clinical Oncology, Princess Margaret Hospital, Kwai Chung, Hong Kong.
Inda SoongDepartment of Clinical Oncology, Pamela Youde Nethersole Eastern Hospital, Chai Wan, Hong Kong.
Ting-Ying NgDepartment of Clinical Oncology, Tuen Mun Hospital, Tuen Mun, Hong Kong.
Joanne ChiuDepartment of Medicine, Queen Mary Hospital, Pok Fu Lam, Hong Kong.
Miranda ChanDepartment of Surgery, Kwong Wah Hospital, Yau Ma Tei, Hong Kong.
Sharon Wing-Wai ChanDepartment of Surgery, United Christian Hospital, Kwun Tong, Hong Kong.
Ting-Ting WongDepartment of Surgery, Hong Kong Breast Cancer Foundation, North Point, Hong Kong.
Yolanda Ho-Yan ChanDepartment of Surgery, Breast Health Clinic, CUHK Medical Centre, Sha Tin, Hong Kong.
Lawrence Pui-Ki LiDepartment of Surgery, Hong Kong Breast Cancer Foundation, North Point, Hong Kong.
Chun-Chung YauDepartment of Surgery, Hong Kong Breast Cancer Foundation, North Point, Hong Kong.
Wai-Ka HungDepartment of Surgery, Hong Kong Breast Cancer Foundation, North Point, Hong Kong.
Polly Suk-Yee CheungDepartment of Surgery, Hong Kong Breast Cancer Foundation, North Point, Hong Kong.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: In Hong Kong, breast cancer is the commonest female cancer. In addition to intrinsic risk factors that cannot be modified, other factors may be potentially modifiable. The objective of this report was to determine modifiable risk factors in association with breast cancer among Chinese women in our locality. Methods: This is a case-control study that enrolled breast cancer patients from the Hong Kong Breast Cancer Registry and healthy matched controls from the local community between 2014 and 2017. Potential risk factors were analyzed using multiple logistic regression. Results: In total, 5186 breast cancer patients and 5571 controls were recruited. Several modifiable risk factors were identified. Self-perceived high stress level (adjusted odd ratios [AOR]= 3.44; 95% confidence intervals [CI] = 3.13-3.78), dairy-rich diet (AOR = 3.33; 95% CI = 2.01-5.52), delayed child-bearing (AOR = 2.23; 95% CI = 1.79-2.79), meat-rich diet (AOR = 1.77; 95% CI = 1.54-2.04), ever use of oral contraceptives (AOR = 1.34; 95% CI = 1.22-1.47), nulliparity (AOR = 1.21; 95% CI = 1.08-1.35), and being overweight/obese (AOR = 1.21; 95% CI = 1.10-1.32) were found to be associated with an increased risk of breast cancer. On the other hand, breastfeeding (AOR = 0.76; 95% CI = 0.69-0.83) and exercise (odds ratio = 0.62; 95% CI = 0.56-0.68) were associated with decreased risk. Conclusions: In our locality, high-stress level, meat- and dairy-rich diet, reproductive history, use of oral contraceptives, and being overweight/obese were identified to be modifiable risk factors for breast cancer. Lifestyle modification may help reduce breast cancer incidence in the coming decades.

Indexed as

breast cancerChinesedietexerciseModifiable risk factorstress level

Identifiers

PMID39868354
PMCPMC11760132

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.