Evidence map›Paper›PMID 39868347›Full record

ArticleJournal of orthopaedic translation2025

Bioabsorbable magnesium-based bulk metallic glass composite (BMGC) for improved medial opening wedge high tibial osteotomy in knee osteoarthritis.

Kuan-Hao Chen, Pei-Chun Wong, Lekha Rethi, Wei-Ru Wang, Chieh-Ying Chen, Pei-Hua Tsai, Jason Shian-Ching Jang, Chun-Li Lin, Chih-Hwa Chen, Andrew E-Y Chuang

Erratum issuedAbstract read
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In one paragraph

Article in Journal of orthopaedic translation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. [Research progress in biomechanics of different fixation methods for medial opening-wedge high tibial osteotomy].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2025
    Review
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Kuan-Hao ChenGraduate Institute of Biomedical Materials and Tissue Engineering, College of Biomedical Engineering, Taipei Medical University, 6F Biomedical Technology Building, No. 301, Yuantong Rd., Zhonghe Dist., New Taipei City, 23564, Taiwan.
Pei-Chun WongGraduate Institute of Biomedical Optomechatronics, College of Biomedical Engineering, Taipei Medical University, 6F Biomedical Technology Building, No. 301, Yuantong Rd., Zhonghe Dist., New Taipei City, 23564, Taiwan.
Lekha RethiDepartment of Orthopedics, Shuang Ho Hospital, Taipei Medical University, No.291, Zhongzheng Rd., Zhonghe District, New Taipei City, 23561, Taiwan.
Wei-Ru WangGraduate Institute of Biomedical Materials and Tissue Engineering, College of Biomedical Engineering, Taipei Medical University, 6F Biomedical Technology Building, No. 301, Yuantong Rd., Zhonghe Dist., New Taipei City, 23564, Taiwan.
Chieh-Ying ChenSchool of Biomedical Engineering, College of Biomedical Engineering, Taipei Medical University, No.250 Wuxing Street., Xinyi Dist., Taipei City, 11031, Taiwan.
Pei-Hua TsaiInstitute of Material Science and Engineering, National Central University, No. 300, Zhongda Rd., Zhongli District, Taoyuan City, 32001, Taiwan.
Jason Shian-Ching JangInstitute of Material Science and Engineering, National Central University, No. 300, Zhongda Rd., Zhongli District, Taoyuan City, 32001, Taiwan.
Chun-Li LinDepartment of Biomedical Engineering, Medical Device Innovation & Translation Center, National Yang Ming Chaio Tung University, No. 155, Sec. 2, Linong St., Beitou Dist., Taipei City, 112304, Taiwan.
Chih-Hwa ChenDepartment of Orthopedics, Shuang Ho Hospital, Taipei Medical University, No.291, Zhongzheng Rd., Zhonghe District, New Taipei City, 23561, Taiwan.
Andrew E-Y ChuangGraduate Institute of Biomedical Materials and Tissue Engineering, College of Biomedical Engineering, Taipei Medical University, 6F Biomedical Technology Building, No. 301, Yuantong Rd., Zhonghe Dist., New Taipei City, 23564, Taiwan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and objective: Osteoarthritis is a widespread and debilitating condition, particularly affecting the medial compartment of knee joint due to varus knee deformities. Medial opening wedge high tibial osteotomy (MOWHTO) has emerged as an effective treatment, but it comes with challenges like fractures, correction loss, and nonunion, leading to unsatisfactory results in up to 26 % of patients. In response, our study explores the potential of a bioabsorbable magnesium-based bulk metallic glass composite (Mg Methods: Our comprehensive study includes composite fabrication, mechanical property evaluations, in vitro degradation tests, cell viability assessments, cell migration assays, calcium deposition analyses, and osteoblast differentiation investigations. In vivo experiments were commenced for assessing biological effects and bone growth of the Mg Results: The findings indicate that the Mg Conclusion: In conclusion, our research introduces an innovative Mg The translational potential of this article: This article focuses on meeting the advantages of a novel magnesium-based BMGC with the clinical unmet need of MOWHTO surgeries. If properly developed, the results of this article have significant potential of translation to other temporary orthopedic implants under load-bearing conditions.

Indexed as

Bulk metallic glass compositeEnhanced bone healingMedial opening wedge high tibial osteotomyOsteoarthritis

Identifiers

PMID39868347
PMCPMC11763224

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.