Evidence map›Paper›PMID 39868334›Full record

ArticlebioRxiv : the preprint server for biology2025

Microglia regulate nucleus accumbens synaptic development and circuit function underlying threat avoidance behaviors.

Michael W Gongwer, Fanny Etienne, Eric N Moca, Megan S Chappell, Sara V Blagburn-Blanco, Jack P Riley, Alexander S Enos, Melody Haratian, Alex Qi, Rocio Rojo and 4 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Michael W GongwerDepartment of Physiology, University of California Los Angeles, CA, USA.ORCID 0000-0002-4506-1224
Fanny EtienneDepartment of Physiology, University of California Los Angeles, CA, USA.ORCID 0000-0002-1461-0809
Eric N MocaDepartment of Physiology, University of California Los Angeles, CA, USA.
Megan S ChappellDepartment of Physiology, University of California Los Angeles, CA, USA.
Sara V Blagburn-BlancoDepartment of Physiology, University of California Los Angeles, CA, USA.
Jack P RileyDepartment of Physiology, University of California Los Angeles, CA, USA.
Alexander S EnosDepartment of Physiology, University of California Los Angeles, CA, USA.
Melody HaratianDepartment of Physiology, University of California Los Angeles, CA, USA.
Alex QiDepartment of Psychiatry, University of California Los Angeles, CA, USA.
Rocio RojoInstitution for Regeneration and Repair, University of Edinburgh, Scotland.
Scott A WilkeDepartment of Psychiatry, University of California Los Angeles, CA, USA.
Clare PridansInstitution for Regeneration and Repair, University of Edinburgh, Scotland.
Laura A DeNardoDepartment of Physiology, University of California Los Angeles, CA, USA.ORCID 0000-0002-7607-4773
Lindsay M De BiaseDepartment of Physiology, University of California Los Angeles, CA, USA.ORCID 0000-0003-0177-5601

Funding

UCLA-Caltech Medical Scientist Training ProgramT32GM008042 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI AJIJOLA, OLUJIMI A, DAWSON, DAVID WAYNE · 1985 to 2023
$29.9M
Training Grant in Neurobehavioral GeneticsT32NS048004 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BEARDEN, CARRIE E, OPHOFF, ROEL A · 2004 to 2025
$5.8M
Prefrontal circuits underlying the maturation of learned avoidanceR01MH127214 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Laura Anne DeNardo · 2022 to 2026
$2.3M
Investigating circuit-specific effects of high-frequency repetitive transcranial magnetic stimulationF30MH134633 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GONGWER, MICHAEL W. · 2023 to 2024
$81k
NIGMS NIH HHS T32 GM008042NIMH NIH HHS F30 MH134633NIMH NIH HHS R01 MH127214NINDS NIH HHS T32 NS048004
6 · The paper itself

Abstract

While CNS microglia have well-established roles in synapse pruning during neurodevelopment, only a few studies have identified roles for microglia in synapse formation. These studies focused on the cortex and primary sensory circuits during restricted developmental time periods, leaving substantial gaps in our understanding of the early developmental functions of microglia. Here we investigated how the absence of microglia impacts synaptic development in the nucleus accumbens (NAc), a region critical for emotional regulation and motivated behaviors and where dysfunction is implicated in psychiatric disorders that arise early in life. Using a genetically modified mouse that lacks microglia (

Identifiers

PMID39868334
PMCPMC11761117

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.