Evidence map›Paper›PMID 39868327›Full record

ArticlebioRxiv : the preprint server for biology2025

7-ketocholesterol contributes to microglia-driven increases in astrocyte reactive oxygen species in Alzheimer's disease.

Kayalvizhi Radhakrishnan, Yiyu Zhang, Oluwaseun Mustapha, Thaddeus K Weigel, Clint M Upchurch, Xiaodong Tian, Franklin Herbert, Wenyuan Huang, Norbert Leitinger, Ukpong B Eyo and 2 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Kayalvizhi RadhakrishnanCenter for Brain Immunology and Glia, University of Virginia, Charlottesville, VA, USA.
Yiyu ZhangDepartment of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, VA, USA.
Oluwaseun MustaphaDepartment of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, VA, USA.
Thaddeus K WeigelCenter for Brain Immunology and Glia, University of Virginia, Charlottesville, VA, USA.
Clint M UpchurchDepartment of Pharmacology, University of Virginia, Charlottesville, VA, USA.
Xiaodong TianDepartment of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, VA, USA.
Franklin HerbertDepartment of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, VA, USA.
Wenyuan HuangDepartment of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, VA, USA.
Norbert LeitingerDepartment of Pharmacology, University of Virginia, Charlottesville, VA, USA.
Ukpong B EyoCenter for Brain Immunology and Glia, University of Virginia, Charlottesville, VA, USA.ORCID 0000-0002-1294-475X
Huiwang AiDepartment of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, VA, USA.
Heather A FerrisCenter for Brain Immunology and Glia, University of Virginia, Charlottesville, VA, USA.ORCID 0000-0002-6321-3447

Funding

Training in Cell and Molecular BiologyT32GM139787 · NIGMS · UNIVERSITY OF VIRGINIA · PI Bryce Paschal · 2021 to 2026
$2.5M
Fluorescent Redox Indicators to Image Oxidative Stress in Alzheimer's DiseaseRF1AG077773 · NIA · UNIVERSITY OF VIRGINIA · PI AI, HUIWANG · 2022 to 2022
$1.6M
Fluorescent Redox Indicators to Image Oxidative Stress in Alzheimer's DiseaseR01AG077773 · NIA · UNIVERSITY OF VIRGINIA · PI Huiwang Ai · 2025 to 2026
$1.0M
Cholesterol Metabolites as Regulators of NicastrinR56AG077637 · NIA · UNIVERSITY OF VIRGINIA · PI FERRIS, HEATHER · 2022 to 2022
$540k
Myeloid cell ferroptosis in hemorrhagic strokeF32HL182385 · NHLBI · UNIVERSITY OF VIRGINIA · PI Clint Michael Upchurch · 2025 to 2026
$160k
NHLBI NIH HHS F32 HL182385NIA NIH HHS R01 AG077773NIA NIH HHS R56 AG077637NIA NIH HHS RF1 AG077773NIGMS NIH HHS T32 GM139787
6 · The paper itself

Abstract

Oxidative stress is a prominent feature of Alzheimer's disease. Within this context, cholesterol undergoes oxidation, producing the pro-inflammatory product 7-ketocholesterol (7-KC). In this study, we observe elevated levels of 7-KC in the brains of the 3xTg mouse model of AD. To further understand the contribution of 7-KC on the oxidative environment, we developed a method to express a genetically encoded fluorescent hydrogen peroxide (H

Identifiers

PMID39868327
PMCPMC11761689

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.