Genetic changes linked to two different syndromic forms of autism enhance reinforcement learning in early adolescent male but not female mice.

Juliana Chase, Jing-Jing Li, Wan Chen Lin, Lung-Hao Tai, Fernanda Castro, Anne Ge Collins, Linda Wilbrecht

Abstract readPreprint

In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Juliana ChaseDepartment of Neuroscience, University of California, Berkeley, Berkeley, CA, 94720.ORCID 0000-0002-4067-0477

Jing-Jing LiDepartment of Neuroscience, University of California, Berkeley, Berkeley, CA, 94720.ORCID 0000-0001-5230-1049

Wan Chen LinDepartment of Neuroscience, University of California, Berkeley, Berkeley, CA, 94720.ORCID 0009-0000-1713-3537

Lung-Hao TaiDepartment of Neuroscience, University of California, Berkeley, Berkeley, CA, 94720.

Fernanda CastroCurrent address: Cellular & Molecular Pharmacology, University of California, San Francisco, Mission Bay, CA 94143.

Anne Ge CollinsDepartment of Psychology, University of California, Berkeley, Berkeley, CA, 94720.ORCID 0000-0003-3751-3662

Linda WilbrechtDepartment of Neuroscience, University of California, Berkeley, Berkeley, CA, 94720.ORCID 0000-0003-3492-8141

Funding

Strengths and weaknesses in learning in mice with ASD risk genesR01MH134514 · NIMH · UNIVERSITY OF CALIFORNIA BERKELEY · PI Linda E Wilbrecht · 2023 to 2026

$2.4M

NIMH NIH HHS R01 MH134514

6 · The paper itself

Abstract

Autism Spectrum Disorder (ASD) is characterized by restricted and repetitive behaviors and social differences, both of which may manifest, in part, from underlying differences in corticostriatal circuits and reinforcement learning. Here, we investigated reinforcement learning in developing mice with mutations in either

Identifiers

PMID39868311

DOI10.1101/2025.01.15.633099

PMCPMC11760717

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.