In one paragraphArticle in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
28 authors.
Mette Q LudwigNovo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0002-7814-3859 Bernd CoesterNovo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0003-3747-0076 Desiree GordianDepartments of Internal Medicine, University of Michigan and Molecular and Integrative Physiology, Ann Arbor, Michigan, USA.ORCID 0000-0002-3801-776X Shad HassanNovo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark.ORCID 0009-0000-9751-0098 Abigail J TomlinsonDepartments of Internal Medicine, University of Michigan and Molecular and Integrative Physiology, Ann Arbor, Michigan, USA.ORCID 0000-0002-4192-9639 Mouhamadoul Habib ToureDepartments of Internal Medicine, University of Michigan and Molecular and Integrative Physiology, Ann Arbor, Michigan, USA.
Oliver P ChristensenNovo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0001-9705-4053 Anja Moltke-PrehnNovo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark.
Jenny M BrownNovo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0002-5072-4491 Dylan M RauschNovo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0001-6095-4891 Anika GowdaDepartments of Internal Medicine, University of Michigan and Molecular and Integrative Physiology, Ann Arbor, Michigan, USA.
Iris WuDepartments of Internal Medicine, University of Michigan and Molecular and Integrative Physiology, Ann Arbor, Michigan, USA.
Stace KernodleDepartments of Internal Medicine, University of Michigan and Molecular and Integrative Physiology, Ann Arbor, Michigan, USA.ORCID 0000-0001-7750-8804 Victoria DongDepartments of Internal Medicine, University of Michigan and Molecular and Integrative Physiology, Ann Arbor, Michigan, USA.
Mike Ayensu-MensahDepartments of Internal Medicine, University of Michigan and Molecular and Integrative Physiology, Ann Arbor, Michigan, USA.
Paul V SabatiniDepartments of Internal Medicine, University of Michigan and Molecular and Integrative Physiology, Ann Arbor, Michigan, USA.ORCID 0000-0001-6613-566X Jae Hoon ShinDepartments of Internal Medicine, University of Michigan and Molecular and Integrative Physiology, Ann Arbor, Michigan, USA.ORCID 0000-0001-5247-4345 Melissa KirigitiOregon National Primate Research Center, Oregon Health & Science University, Beaverton, Oregon, USA.ORCID 0000-0002-2570-777X Kristoffer L EgerodNovo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0003-2781-1594 Paul KievitOregon National Primate Research Center, Oregon Health & Science University, Beaverton, Oregon, USA.ORCID 0000-0003-1989-2478 Martin G MyersDepartments of Internal Medicine, University of Michigan and Molecular and Integrative Physiology, Ann Arbor, Michigan, USA.ORCID 0000-0001-9468-2046 Tune H PersNovo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0003-0207-4831 Funding
Upgrade of confocal microscopy at the Oregon National Primate Research CenterP51OD011092 · OD · OREGON HEALTH & SCIENCE UNIVERSITY · PI Bonnie J. Nagel · 2012 to 2026
$203.9MDefining roles for area postrema neuron cell types in food intake and nauseaR01DK132008 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Paulette B. Goforth, Martin G Myers · 2023 to 2026
$2.6MNIDDK NIH HHS R01 DK132008NIH HHS P51 OD011092
6 · The paper itselfAbstract
Amylin analogs, including potential anti-obesity therapies like cagrilintide, act on neurons in the brainstem dorsal vagal complex (DVC) that express calcitonin receptors (CALCR). These receptors, often combined with receptor activity-modifying proteins (RAMPs), mediate the suppression of food intake and body weight. To understand the molecular and neural mechanisms of cagrilintide action, we used single-nucleus RNA sequencing to define 89 cell populations across the rat, mouse, and non-human primate caudal brainstem. We then integrated spatial profiling to reveal neuron distribution in the rat DVC. Furthermore, we compared the acute and long-term transcriptional responses to cagrilintide across DVC neurons of rats, which exhibit strong cagrilintide responsiveness, and mice, which respond poorly to cagrilintide over the long term. We found that cagrilintide promoted long-term transcriptional changes, including increased prolactin releasing hormone (
Identifiers
PMID39868309
PMCPMC11760743
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