Evidence map›Paper›PMID 39868293›Full record

ArticlebioRxiv : the preprint server for biology2025

DUSP12 promotes cell cycle progression and protects cells from cell death by regulating ZPR9.

Mai Abdusamad, Xiao Guo, Ivan Ramirez, Erick F Velasquez, Whitaker Cohn, Ankur A Gholkar, Julian P Whitelegge, Jorge Z Torres

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Mai AbdusamadDepartment of Chemistry and Biochemistry, University of California, Los Angeles, CA 90095, USA.
Xiao GuoDepartment of Chemistry and Biochemistry, University of California, Los Angeles, CA 90095, USA.
Ivan RamirezDepartment of Chemistry and Biochemistry, University of California, Los Angeles, CA 90095, USA.
Erick F VelasquezDepartment of Chemistry and Biochemistry, University of California, Los Angeles, CA 90095, USA.
Whitaker CohnPasarow Mass Spectrometry Laboratory, The Jane and Terry Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.
Ankur A GholkarDepartment of Chemistry and Biochemistry, University of California, Los Angeles, CA 90095, USA.
Julian P WhiteleggePasarow Mass Spectrometry Laboratory, The Jane and Terry Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.
Jorge Z TorresDepartment of Chemistry and Biochemistry, University of California, Los Angeles, CA 90095, USA.ORCID 0000-0002-2158-889X

Funding

Transgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MILES Frome WILKINSON · 2003 to 2026
$40.4M
Research Training in Cell and Molecular BiologyT32GM145388 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Jorge Torres · 2022 to 2026
$5.2M
Investigating the Cell Division MachineryR35GM139539 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI TORRES, JORGE · 2021 to 2025
$2.2M
Defining the role of DUSP12 in the regulation of cell division and apoptosis.F31GM154466 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ABDUSAMAD, MAI · 2024 to 2025
$66k
NIDDK NIH HHS P30 DK063491NIGMS NIH HHS F31 GM154466NIGMS NIH HHS R35 GM139539NIGMS NIH HHS T32 GM145388
6 · The paper itself

Abstract

Protein phosphatases are critical for regulating cell signaling, cell cycle, and cell fate decisions, and their dysregulation leads to an array of human diseases like cancer. The dual specificity phosphatases (DUSPs) have emerged as important factors driving tumorigenesis and cancer therapy resistance. DUSP12 is a poorly characterized atypical DUSP widely conserved throughout evolution. Although no direct substrate has been firmly established, DUSP12 that has been implicated in protecting cells from stress, regulating ribosomal biogenesis, and modulating cellular DNA content. In this study, we used affinity- and proximity-based biochemical purification approaches coupled to mass spectrometry to identify the zinc finger protein ZPR9 as a novel DUSP12 interactor, which was validated by in-cell and

Indexed as

cell cyclecell deathcell divisioncell survivaldual specificity phosphatase 12 (DUSP12)hYVH1mitosisphosphorylationzinc finger protein 622 (ZNF622)zinc finger protein 9 (ZPR9)

Identifiers

PMID39868293
PMCPMC11760727

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.