Evidence map›Paper›PMID 39868242›Full record

ArticlebioRxiv : the preprint server for biology2025

Genetically encoded mechano-sensors with versatile readouts and compact size.

Yuan Ren, Jie Yang, Takumi Saito, Oliver Glomb, Avinash Kumar, Sayed Iman Mousavi, Brigitte Naughton, Christina de Fontnouvelle, Barbara Fujita, Zhiqun Xi and 4 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Yuan RenDepartment of Molecular Biophysics and Biochemistry; Yale University, New Haven, CT, USA.ORCID 0000-0001-7155-7664
Jie YangDepartment of Cell Biology, Yale University School of Medicine; New Haven, CT 06520, USA.ORCID 0000-0002-3522-0906
Takumi SaitoDepartment of Molecular Biophysics and Biochemistry; Yale University, New Haven, CT, USA.ORCID 0000-0001-6433-6302
Oliver GlombInstitute of Clinical Anatomy and Cell Analysis, University of Tübingen, 72074 Tübingen, Germany.ORCID 0000-0002-1762-5037
Avinash KumarDepartment of Cell Biology, Yale University School of Medicine; New Haven, CT 06520, USA.
Sayed Iman MousaviDepartment of Molecular Biophysics and Biochemistry; Yale University, New Haven, CT, USA.
Brigitte NaughtonDepartment of Molecular Biophysics and Biochemistry; Yale University, New Haven, CT, USA.ORCID 0000-0001-6233-3319
Christina de FontnouvelleDepartment of Molecular Biophysics and Biochemistry; Yale University, New Haven, CT, USA.
Barbara FujitaDepartment of Molecular Biophysics and Biochemistry; Yale University, New Haven, CT, USA.
Zhiqun XiDepartment of Cell Biology, Yale University School of Medicine; New Haven, CT 06520, USA.
Christian SchliekerDepartment of Molecular Biophysics and Biochemistry; Yale University, New Haven, CT, USA.
Shaul YogevDepartment of Neuroscience, Yale University School of Medicine; New Haven, CT 06520, USA.ORCID 0000-0003-2427-2142
Yongli ZhangDepartment of Molecular Biophysics and Biochemistry; Yale University, New Haven, CT, USA.ORCID 0000-0001-7079-7973
Julien BerroDepartment of Molecular Biophysics and Biochemistry; Yale University, New Haven, CT, USA.ORCID 0000-0002-9560-8646

Funding

Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Aric L Daul, Ann E. Rougvie · 2012 to 2026
$7.5M
Programming cellular behavior by mechanical forcesR01EB037112 · NIBIB · YALE UNIVERSITY · PI Julien Berro, Alexander Arthur Green · 2024 to 2026
$7.2M
Kinesin Motors and Microtubule-based TraffickingR35GM131744 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Kristen J. Verhey · 2019 to 2026
$6.3M
Single-molecule studies of SNARE assembly and lipid transferR35GM131714 · NIGMS · YALE UNIVERSITY · PI Yongli Zhang · 2019 to 2026
$5.0M
Molecular mechanisms of force production and force sensing during clathrin-mediated endocytosisR01GM115636 · NIGMS · YALE UNIVERSITY · PI Julien Berro · 2016 to 2026
$4.7M
New strategy to measure forces at the molecular scale in vivoR21GM132661 · NIGMS · YALE UNIVERSITY · PI BERRO, JULIEN · 2019 to 2020
$461k
NIBIB NIH HHS R01 EB037112NIGMS NIH HHS R01 GM115636NIGMS NIH HHS R21 GM132661NIGMS NIH HHS R35 GM131714NIGMS NIH HHS R35 GM131744NIH HHS P40 OD010440
6 · The paper itself

Abstract

Mechanical forces are critical for virtually all fundamental biological processes, yet quantification of mechanical forces at the molecular scale

Identifiers

PMID39868242
PMCPMC11760715

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.