Evidence map›Paper›PMID 39868218›Full record

ArticlebioRxiv : the preprint server for biology2025

Kynurenine Metabolism is Associated with Antidepressant Response to Selective Serotonin Reuptake Inhibitors.

Ryan Rampersaud, Klara Suneson, Gwyneth W Y Wu, Victor I Reus, Daniel Lindqvist, Tiffany C Ho, Dieter J Meyerhoff, Michael R Irwin, Owen M Wolkowitz, Synthia H Mellon and 1 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Ryan RampersaudWeill Institute for Neurosciences and Department of Psychiatry and Behavioral Sciences, University of California San Francisco, San Francisco, CA, 94143, USA.
Klara SunesonUnit for Biological and Precision Psychiatry, Department of Clinical Sciences Lund, Lund University, Sweden.
Gwyneth W Y WuWeill Institute for Neurosciences and Department of Psychiatry and Behavioral Sciences, University of California San Francisco, San Francisco, CA, 94143, USA.
Victor I ReusWeill Institute for Neurosciences and Department of Psychiatry and Behavioral Sciences, University of California San Francisco, San Francisco, CA, 94143, USA.
Daniel LindqvistUnit for Biological and Precision Psychiatry, Department of Clinical Sciences Lund, Lund University, Sweden.
Tiffany C HoDepartment of Psychology, University of California Los Angeles, Los Angeles, CA, 90095, USA.
Dieter J MeyerhoffDepartment of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco CA, 94143, USA and Center for Imaging of Neurodegenerative Diseases (CIND), San Francisco VA Medical Center, San Francisco, CA, USA.
Michael R IrwinDepartment of Psychiatry and Biobehavioral Sciences, University of California Los Angeles, Los Angeles, CA, 90095, USA.
Owen M WolkowitzWeill Institute for Neurosciences and Department of Psychiatry and Behavioral Sciences, University of California San Francisco, San Francisco, CA, 94143, USA.
Synthia H MellonDepartment of Obstetrics, Gynecology & Reproductive Sciences, University of California, San Francisco, CA 94143, USA.
Lena BrundinDepartment of Neurodegenerative Science, Van Andel Institute, Grand Rapids, MI 49503, USA.

Funding

UCSF CLINICAL AND TRANSLATIONAL SCIENCE INSTITUTEUL1RR024131 · NCRR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI JOHNSTON, S. CLAIBORNE · 2006 to 2011
$111.2M
NRSA Training CoreTL1TR001871 · NCATS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KANAYA, ALKA M., SOMSOUK, MA · 2016 to 2025
$10.1M
Cell Aging in Major DepressionR01MH083784 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI EPEL, ELISSA S., MELLON, SYNTHIA H · 2010 to 2020
$6.7M
Gut Microbiota Dysbiosis in Major Depressive Disorder is Associated with Altered Production of Aryl Hydrocarbon Receptor Ligands and Altered Microglia FunctionK08MH126192 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI RAMPERSAUD, RYAN · 2021 to 2024
$805k
NCATS NIH HHS TL1 TR001871NCRR NIH HHS UL1 RR024131NIMH NIH HHS K08 MH126192NIMH NIH HHS R01 MH083784
6 · The paper itself

Abstract

Alterations in the kynurenine pathway, and in particular the balance of neuroprotective and neurotoxic metabolites, have been implicated in the pathophysiology of Major Depressive Disorder (MDD) and antidepressant treatment response. In this study, we examined the relationship between changes in kynurenine pathway activity (Kynurenine/Tryptophan ratio), focusing on the balance of neuroprotective-to neurotoxic metabolites (Kynurenic Acid/Quinolinic Acid and Kynurenic Acid/3-Hydroxykynurenine ratios), and response to 8 weeks of selective serotonin reuptake inhibitor (SSRI) treatment, including early changes four weeks after SSRI initiation. Additionally, we examined relationships between kynurenine metabolite ratios and three promising biomarkers of depression and antidepressant response: amygdala/hippocampal volume, and glutamate metabolites in the anterior cingulate cortex. Responders showed an increase in the Kynurenic Acid/3-Hydroxykynurenine ratio by week 8 (

Identifiers

PMID39868218
PMCPMC11761690

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.