Evidence map›Paper›PMID 39868199›Full record

ArticlebioRxiv : the preprint server for biology2025

Assessment of developmental neurotoxicology-associated alterations in neuronal architecture and function using

Javier Huayta, Sarah Seay, Joseph Laster, Nelson A Rivera, Abigail S Joyce, P Lee Ferguson, Heileen Hsu-Kim, Joel N Meyer

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Javier HuaytaNicholas School of the Environment, Duke University, Durham, North Carolina, USA.
Sarah SeayNicholas School of the Environment, Duke University, Durham, North Carolina, USA.
Joseph LasterNicholas School of the Environment, Duke University, Durham, North Carolina, USA.
Nelson A RiveraPratt School of Engineering, Duke University, Durham, North Carolina, USA.
Abigail S JoycePratt School of Engineering, Duke University, Durham, North Carolina, USA.
P Lee FergusonPratt School of Engineering, Duke University, Durham, North Carolina, USA.
Heileen Hsu-KimPratt School of Engineering, Duke University, Durham, North Carolina, USA.
Joel N MeyerNicholas School of the Environment, Duke University, Durham, North Carolina, USA.ORCID 0000-0003-1219-0983

Funding

Zebrafish as a Detector of Organophosphate ExposureP42ES010356 · NIEHS · DUKE UNIVERSITY · PI AMY H HERRING · 2000 to 2026
$56.2M
Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Ann E. Rougvie · 2012 to 2026
$7.5M
Which mechanisms of pollutant-induced mitochondrial dysfunction cause dopaminergic neurodegeneration?R01ES034270 · NIEHS · DUKE UNIVERSITY · PI MEYER, JOEL NEWMAN · 2023 to 2025
$1.2M
NIEHS NIH HHS P42 ES010356NIEHS NIH HHS R01 ES034270NIH HHS P40 OD010440
6 · The paper itself

Abstract

Few of the many chemicals that regulatory agencies are charged with assessing for risk have been carefully tested for developmental neurotoxicity (DNT). To speed up testing efforts, as well as to reduce the use of vertebrate animals, great effort is being devoted to alternate laboratory models for testing DNT. A major mechanism of DNT is altered neuronal architecture resulting from chemical exposure during neurodevelopment.

Indexed as

altered behaviorCaenorhabditis elegansDevelopmental neurotoxicityDNTneurodegeneration

Identifiers

PMID39868199
PMCPMC11761668

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.