Evidence map›Paper›PMID 39868190›Full record

ArticlebioRxiv : the preprint server for biology2025

Reactivation of an Embryonic Cardiac Neural Crest Transcriptional Subcircuit During Zebrafish Heart Regeneration.

Rekha M Dhillon-Richardson, Alexandra K Haugan, Luke W Lyons, Joseph K McKenna, Marianne E Bronner, Megan L Martik

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Rekha M Dhillon-RichardsonDepartment of Molecular and Cell Biology, University of California, Berkeley; Berkeley, CA, USA.ORCID 0009-0002-8721-9613
Alexandra K HauganDepartment of Molecular and Cell Biology, University of California, Berkeley; Berkeley, CA, USA.ORCID 0000-0002-2986-5556
Luke W LyonsDepartment of Molecular and Cell Biology, University of California, Berkeley; Berkeley, CA, USA.ORCID 0009-0000-9168-8880
Joseph K McKennaDepartment of Molecular and Cell Biology, University of California, Berkeley; Berkeley, CA, USA.ORCID 0000-0002-3921-4933
Marianne E BronnerDivision of Biology, California Institute of Technology; Pasadena, CA, USA.ORCID 0000-0003-4274-1862
Megan L MartikDepartment of Molecular and Cell Biology, University of California, Berkeley; Berkeley, CA, USA.ORCID 0000-0003-1186-4085

Funding

Molecular Biology Across Scales Training ProgramT32GM148378 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI David Bilder, Elcin Unal · 2023 to 2026
$7.3M
Genetic Dissection of Cells and Organisms Training ProgramT32GM132022 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI Nicole King, NOAH K WHITEMAN · 2019 to 2026
$5.2M
Reactivating regulatory programs for regenerationDP2HL173858 · NHLBI · UNIVERSITY OF CALIFORNIA BERKELEY · PI Megan Lee Martik · 2023 to 2026
$2.4M
Investigating the contributions of neural crest to adult regenerationR00HD100587 · NICHD · UNIVERSITY OF CALIFORNIA BERKELEY · PI MARTIK, MEGAN LEE · 2021 to 2023
$747k
Investigating the contributions of neural crest to adult regenerationK99HD100587 · NICHD · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI MARTIK, MEGAN LEE · 2020 to 2020
$124k
Uncovering the Role of Neural Crest Gene Regulatory Networks in Cardiac RegenerationF31HL176141 · NHLBI · UNIVERSITY OF CALIFORNIA BERKELEY · PI HAUGAN, ALEXANDRA K · 2024 to 2025
$86k
NHLBI NIH HHS DP2 HL173858NHLBI NIH HHS F31 HL176141NICHD NIH HHS K99 HD100587NICHD NIH HHS R00 HD100587NIGMS NIH HHS T32 GM132022NIGMS NIH HHS T32 GM148378
6 · The paper itself

Abstract

During vertebrate development, the heart primarily arises from mesoderm, with crucial contributions from cardiac neural crest cells that migrate to the heart and form a variety of cardiovascular derivatives. Here, by integrating bulk and single cell RNA-seq with ATAC-seq, we identify a gene regulatory subcircuit specific to migratory cardiac crest cells composed of key transcription factors

Identifiers

PMID39868190
PMCPMC11760256

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.