Evidence map›Paper›PMID 39868176›Full record

ArticlebioRxiv : the preprint server for biology2025

Crb3 and NF2: A dynamic duo that controls assembly of the apical junctions and barrier function via Rho/ROCK signaling.

S Fan, S Varadarajan, V Garcia-Hernandez, B Margolis, C A Parkos, A Nusrat

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

S FanDepartment of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.ORCID 0000-0001-8315-0124
S VaradarajanDepartment of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.ORCID 0000-0002-4473-9435
V Garcia-HernandezDepartment of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.ORCID 0000-0002-2618-5870
B MargolisDepartment of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
C A ParkosDepartment of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.ORCID 0000-0002-2490-7657
A NusratDepartment of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.ORCID 0000-0002-8954-3188

Funding

Regulation of intestinal epithelial barrier function by intercellular junction proteins in health and diseaseR01DK059888 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ASMA NUSRAT · 2001 to 2026
$10.5M
Polarity proteins and intestinal mucosal responses to inflammation and injuryR01DK129214 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI NUSRAT, ASMA, PARKOS, CHARLES A · 2022 to 2025
$1.9M
NIDDK NIH HHS R01 DK059888NIDDK NIH HHS R01 DK129214
6 · The paper itself

Abstract

The gastrointestinal epithelium serves as a critical barrier separating intestinal lumen contents from the underlying tissue environment. Structure and function of the apical junctional complex (AJC), comprising tight and adherens junctions, are essential for establishing and maintaining a polarized and functional epithelial barrier. In this study, we investigated mechanisms by which an apical polarity protein Crumbs homolog 3 (CRB3) regulates AJC assembly and barrier function in primary murine intestinal epithelial cells. Using primary colonic epithelial cells (colonoids) derived from inducible and conditional Crb3 knockdown (Crb3

Indexed as

Apical actomyosin beltCrumbs3Epithelial barrier functionMerlin (NF2)Polarity complexRho/ROCK signaling

Identifiers

PMID39868176
PMCPMC11760739

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.